Pesticidal Mixtures

ABSTRACT

The present invention relates to pesticidal mixtures comprising a component A and a component B, wherein component A is a compound of formula (I) wherein B 1 , B 2 , B 3 , X 1 , X 2 , X 3 , X 4 , Y 1 , Y 2 , Y 3 , R 5 , R 7 , and R 8  are as defined in claim  1  and component B is an insecticide. The present invention also relates to methods of using said mixtures for the control of plant pests.

The present invention relates to mixtures of pesticidally activeingredients and to methods of using the mixtures in the field ofagriculture.

The present invention provides pesticidal mixtures comprising acomponent A and a component B, wherein component A is a compound offormula I

—B¹—B²—B³— is —C═N—O—, —C═N—CH₂— or —N—CH₂—CH₂—;

Y¹ is C—R⁶, CH or nitrogen;Y² and Y³ are independently CH or nitrogen;wherein no more than two of Y¹, Y² and Y³ are nitrogen and wherein Y²and Y³ are not both nitrogen;R⁵ is hydrogen, halogen, cyano, nitro, NH₂, C₁-C₂alkyl, C₁-C₂haloalkyl,C₃-C₅cycloalkyl, C₃-C₅halocycloalkyl, C₁-C₂alkoxy, C₁-C₂haloalkoxy;R⁶ when present together with R⁵ forms a —CH═CH—CH═CH— bridge;R⁷ is hydrogen or methyl;R⁸ is C₁-C₄alkyl, C₁-C₄haloalkyl, C₁-C₄alkyl-O—CH₂—,C₁-C₄haloalkyl-O—CH₂—, C₃-C₆cycloalkyl, C₃-C₆cycloalkyl-CH₂—,C₁-C₄alkyl-S—CH₂—, C₁-C₄alkyl-S(O)—CH₂—, C₁-C₄alkyl-S(O₂)—CH₂—;X² is C—X⁶ or nitrogen;X¹, X³ and X⁶ are independently hydrogen, halogen or trihalomethyl,wherein at least two ofX¹, X³ and X⁶ are not hydrogen;X⁴ is trifluoromethyl, difluoromethyl or chlorodifluoromethyl;and component B is a compound selected froma) a pyrethroid including those selected from the group consisting ofpermethrin, cypermethrin, fenvalerate, esfenvalerate, deltamethrin,cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin, bifenthrin,fenpropathrin, cyfluthrin (including beta cyfluthrin), tefluthrin,ethofenprox, natural pyrethrin, tetramethrin, S-bioallethrin,fenfluthrin, prallethrin and5-benzyl-3-furylmethyl-(E)-(1R,3S)-2,2-dimethyl-3-(2-oxothiolan-3-ylidenemethyl)cyclopropanecarboxylate;b) an organophosphate including those selected from the group consistingof sulprofos, acephate, methyl parathion, azinphos-methyl,demeton-s-methyl, heptenophos, thiometon, fenamiphos, monocrotophos,profenofos, triazophos, methamidophos, dimethoate, phosphamidon,malathion, chlorpyrifos, phosalone, terbufos, fensulfothion, fonofos,phorate, phoxim, pirimiphos-methyl, pirimiphos-ethyl, fenitrothion,fosthiazate and diazinon;c) a carbamate including those selected from the group consisting ofpirimicarb, triazamate, chloethocarb, carbofuran, furathiocarb,ethiofencarb, aldicarb, thiofurox, carbosulfan, bendiocarb, fenobucarb,propoxur, methomyl, thiodicarb and oxamyl;d) a benzoyl urea including those selected from the group consisting ofdiflubenzuron, triflumuron, hexaflumuron, flufenoxuron, lufenuron andchlorfluazuron;e) an organic tin compound selected from the group consisting ofcyhexatin, fenbutatin oxide and azocyclotin;f) a pyrazole including those selected from the group consisting oftebufenpyrad and fenpyroximate;g) a macrolide including those selected from the group consisting ofabamectin, emamectin (e.g. emamectin benzoate), ivermectin, milbemycin,spinosad, azadirachtin and spinetoram;h) an organochlorine compound including those selected from the groupconsisting of endosulfan (in particular alpha-endosulfan), benzenehexachloride, DDT, chlordane and dieldrin;i) an amidine including those selected from the group consisting ofchlordimeform and amitraz;j) a fumigant agent including those selected from the group consistingof chloropicrin, dichloropropane, methyl bromide and metam;k) a neonicotinoid compound including those selected from the groupconsisting of imidacloprid, thiacloprid, acetamiprid, nitenpyram,dinotefuran, thiamethoxam, clothianidin, nithiazine and flonicamid;l) a diacylhydrazine including those selected from the group consistingof tebufenozide, chromafenozide and methoxyfenozide;m) a diphenyl ether including those selected from the group consistingof diofenolan and pyriproxyfen;n) indoxacarb;o) chlorfenapyr;p) pymetrozine;q) a tetramic acid compound including those selected from the groupconsisting of spirotetramat and spirodiclofen, or a tetronic acidcompound including spiromesifen;r) a diamide including those selected from the group consisting offlubendiamide, chlorantraniliprole (Rynaxypyr®) and cyantraniliprole;s) sulfoxaflor;t) metaflumizone;u) fipronil and ethiprole;v) pyrifluqinazon;w) buprofezin;x) diafenthiuron;y)4-[(6-Chloro-pyridin-3-ylmethyl)-(2,2-difluoro-ethyl)-amino]-5H-furan-2-one;z) flupyradifurone.

Compounds in ground a)-z) are insecticidal compounds. In addition,component B may be a nematicidally active biological agent. Thenematicidally active biological agent refers to any biological agentthat has nematicidal activity. The biological agent can be any typeknown in the art including bacteria and fungi. The wording“nematicidally active” refers to having an effect on, such as reductionin damage caused by, agricultural-related nematodes. The nematicidallyactive biological agent can be a bacterium or a fungus. Preferably, thebiological agent is a bacterium. Examples of nematicidally activebacteria include Bacillus firmus, Bacillus cereus, Bacillus subtilis, P.nishizawae and Pasteuria penetrans. A suitable Bacillus firmus strain isstrain CNCM 1-1582 which is commercially available as BioNem™ A suitableBacillus cereus strain is strain CNCM 1-1562. Of both Bacillus strainsmore details can be found in U.S. Pat. No. 6,406,690. Also of interestare Streptomyces spp. such as S. avermitilis, and fungi includingMetarhizium spp. such as M. anisopliae; Pochonia spp. such as P.chlamydosporia.

Compounds of formula I are known to have insecticidal activity. Certainactive ingredient mixtures of a compound of formula I and additionalactive ingredients can enhance the spectrum of action with respect tothe pest to be controlled, For example, the combination of A and B maycause an increase in the expected insecticidal action. This allows, onthe one hand, a substantial broadening of the spectrum of pests that canbe controlled and, on the other hand, increased safety in use throughlower rates of application.

However, besides the actual synergistic action with respect to pestcontrol, the pesticidal compositions according to the invention can havefurther surprising advantageous properties which can also be described,in a wider sense, as synergistic activity. Examples of such advantageousproperties that may be mentioned are: a broadening of the spectrum ofpest control to other pests, for example to resistant strains; areduction in the rate of application of the active ingredients; adequatepest control with the aid of the compositions according to theinvention, even at a rate of application at which the individualcompounds are totally ineffective; advantageous behaviour duringformulation and/or upon application, for example upon grinding, sieving,emulsifying, dissolving or dispensing; increased storage stability;improved stability to light; more advantageous degradability; improvedtoxicological and/or ecotoxicological behaviour; improvedcharacteristics of the useful plants including: emergence, crop yields,more developed root system, tillering increase, increase in plantheight, bigger leaf blade, less dead basal leaves, stronger tillers,greener leaf colour, less fertilizers needed, less seeds needed, moreproductive tillers, earlier flowering, early grain maturity, less plantverse (lodging), increased shoot growth, improved plant vigor, and earlygermination; or any other advantages familiar to a person skilled in theart.

Compounds of formula I may be prepared according to the methodsdescribed in WO08128711, WO2009072621, WO 2010133336, WO 2009097992. Thecomponents B are known, e.g. from “The Pesticide Manual”, FifteenthEdition, Edited by Clive Tomlin, British Crop Protection Council.

The combinations according to the invention may also comprise more thanone of the active components B, if, for example, a broadening of thespectrum of pest control is desired. For instance, it may beadvantageous in the agricultural practice to combine two or threecomponents B with any of the compounds of formula I, or with anypreferred member of the group of compounds of formula I. The mixtures ofthe invention may also comprise other active ingredients in addition tocomponents A and B. In other embodiments the mixtures of the inventionmay include only components A and B as pesticidally active ingredients,e.g. no more than two pesticidally active ingredients.

The compounds of formula (I) may exist in different geometric or opticalisomers or tautomeric forms. This invention covers all such isomers andtautomers and mixtures thereof in all proportions as well as isotopicforms such as deuterated compounds. The invention also covers salts andN-oxides of the compounds of the invention.

Alkyl groups (either alone or as part of a larger group, such asalkoxy-, alkylthio-, alkylsulfinyl-, alkylsulfonyl-, alkylcarbonyl- oralkoxycarbonyl-) can be in the form of a straight or branched chain andare, for example, methyl, ethyl, propyl, prop-2-yl, butyl, but-2-yl,2-methyl-prop-1-yl or 2-methyl-prop-2-yl. The alkyl groups arepreferably C₁-C₆, more preferably C₁-C₄, most preferably C₁-C₃ alkylgroups. Where an alkyl moiety is said to be substituted, the alkylmoiety is preferably substituted by one to four substituents, mostpreferably by one to three substituents.

Halogen is fluorine, chlorine, bromine or iodine.

Haloalkyl groups are alkyl groups which are substituted by one or moreof the same or different halogen atoms and are, for example,difluoromethyl, trifluoromethyl, chlorodifluoromethyl or2,2,2-trifluoro-ethyl.

Preferred substituent definitions are described below and may becombined in any combination, including with original definitions.

Preferably R⁵ is hydrogen, chloro, bromo, fluoro, trifluoromethyl,methyl, ethyl, methoxy, nitro, trifluoromethoxy, cyano, cyclopropyl,more preferably R⁵ is hydrogen, chloro, bromo, fluoro, trifluoromethyl,methyl, ethyl, nitro, cyano, cyclopropyl, even more preferably R⁵ ishydrogen, chloro, bromo, fluoro, methyl, or trifluoromethyl. Mostpreferably R⁵ is hydrogen.

Preferably R⁷ is methyl.

Preferably R⁸ is C₁-C₄alkyl, C₁-C₄haloalkyl, C₁-C₄alkyl-O—CH₂—,C₁-C₄haloalkyl-O—CH₂—, C₃-C₆cycloalkyl, C₃-C₆cycloalkyl-CH₂—,C₁-C₄alkyl-S(O)—CH₂—, C₁-C₄alkyl-S(O₂)—CH₂—, more preferably C₁-C₄alkyl,C₁-C₄alkyl-O—CH₂—, C₃-C₄cycloalkyl, or C₃-C₄cycloalkyl-CH₂—, morepreferably C₁-C₂alkyl, C₁-C₂alkyl-O—CH₂—, C₃-C₄cycloalkyl, orC₃-C₄cycloalkyl-CH₂—, more preferably methyl, ethyl, CH₃—O—CH₂—,cyclopropyl or cyclopropyl-CH₂—, CF₃CH₂, CH₃S—CH₂, CH₃S(O₂)—CH₂, evenmore preferably methyl, ethyl, CH₃—O—CH₂—, cyclopropyl orcyclopropyl-CH₂—, most preferably cyclopropyl.

Preferably Y¹ is CH, Y² is CH, Y³ is CH, or Y¹ is N, Y² is CH, Y³ is CH,or Y¹ is N, Y² is N, Y³ is CH, or Y¹ is CH, Y² is N, Y³ is CH, or Y¹ isCH, Y² is CH, Y³ is N. Preferably Y¹ is CH, Y² is CH and Y³ is CH.

Preferably X² is C—X⁶;

Preferably X¹, X³ and X⁶ are independently hydrogen, halogen ortrifluoromethyl, wherein at least two of X¹, X³ and X⁶ are not hydrogen.More preferably X¹, X³ and X⁶ are independently hydrogen, chloro, bromoor trifluoromethyl, wherein at least two of X¹, X³ and X⁶ are nothydrogen. Preferably at least two of X¹, X³ and X⁶ are (independently)chloro, bromo or trifluoromethyl.

For example X¹ is chloro, X² is CH, X³ is chloro, or X¹ is chloro, X² isC—F, X³ is hydrogen, or X¹ is fluoro, X² is C—Cl, X³ is hydrogen, or X¹is chloro, X² is C—Cl, X³ is hydrogen, or X¹ is chloro, X² is C—Br, X³is chloro, or X¹ is chloro, X² is C—F, X³ is chloro, or X¹ is chloro, X²is C—Cl, X³ is chloro, or X¹ is chloro, X² is C—I, X³ is chloro, or X¹is fluoro, X² is C—F, X³ is fluoro, or X¹ is chloro, X² is CH, X³ isbromo, or X¹ is chloro, X² is CH, X³ is fluoro, or X¹ is chloro, X² isCH, X³ is trifluoromethyl, or X¹ is chloro, X² is C—Cl, X³ istrifluoromethyl, or X¹ is trifluoromethyl, X² is CH, X³ istrifluoromethyl, or X¹ is trifluoromethyl, X² is C—Cl, X³ istrifluoromethyl, or X¹ is trifluoromethyl, X² is CH, X³ is hydrogen, orX¹ is chloro, X² is N, X³ is chloro, or X¹ is trifluoromethyl, X² is N,X³ is trifluoromethyl. More preferably X¹ is chloro, X² is CH, X³ ischloro or X¹ is trifluoromethyl, X² is CH, X³ is trifluoromethyl or X¹is chloro, X² is CH, X³ is trifluoromethyl or X¹ is chloro, X² is C—Cl,X³ is chloro, or X¹ is chloro, X² is C—F, X³ is chloro, most preferablyX¹ is trifluoromethyl, X² is CH, X³ is trifluoromethyl.

Preferably X⁴ is trifluoromethyl, or chlorodifluoromethyl, morepreferably trifluoromethyl.

In one group of compounds —B¹—B²—B³— is —C═N—O—.

In another group of compounds —B¹—B²—B³— is —C═N—CH₂—.

In another group of compounds —B¹—B²—B³— is —N—CH₂—CH₂—.

In another group of compounds —B¹—B²—B— is —C═N—CH₂— or —N—CH₂—CH₂—.

In another group of compounds Y¹ is C—R⁶ and R⁶ together with R⁵ forms a—CH═CH—CH═CH— bridge.

In another group of compounds X² is C—X⁶, Y¹, Y² and Y³ are C—H.

In another of compounds X² is C—X⁶, Y¹, Y² and Y³ are C—H and R⁵ ishydrogen.

In another group of compounds —B¹—B²—B³— is —C═N—CH₂—, X² is C—X⁶, Y¹,Y², and Y³ are C—H, R⁵ is hydrogen, R⁸ is C₁-C₂alkyl, C₁-C₂alkyl-O—CH₂—,C₃-C₄cycloalkyl, or C₃-C₄cycloalkyl-CH₂—.

In another group of compounds —B¹—B²—B³— is —C═N—CH₂—, X² is C—X⁶, Y¹,Y², and Y³ are C—H, R⁵ is hydrogen, R⁸ is methyl, ethyl, CH₃—O—CH₂—,cyclopropyl or cyclopropyl-CH₂—, preferably cyclopropyl.

In another group of compounds —B¹—B²—B³— is —C═N—CH₂—, X² is C—X⁶, Y¹,Y² and Y³ are C—H, R⁵ is hydrogen, R⁸ is C₁-C₂alkyl, C₁-C₂alkyl-O—CH₂—,C₃-C₄cycloalkyl, or C₃-C₄cycloalkyl-CH₂—X⁴ is trifluoromethyl.

In another group of compounds —B¹—B²—B³— is —C═N—CH₂—, X² is C—X⁶, Y¹,Y², and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is C₁-C₂alkyl,C₁-C₂alkyl-O—CH₂—, C₃-C₄cycloalkyl, or C₃-C₄cycloalkyl-CH₂—.

In another group of compounds —B¹—B²—B³— is —C═N—CH₂—, X² is C—X⁶, Y¹,Y², and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl, ethyl,CH₃—O—CH₂—, cyclopropyl or cyclopropyl-CH₂—, preferably cyclopropyl.

In another group of compounds —B¹—B²—B³— is —C═N—CH₂—, X² is C—X⁶, Y¹,Y² and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is C₁-C₂alkyl,C₁-C₂alkyl-O—CH₂—, C₃-C₄cycloalkyl, or C₃-C₄cycloalkyl-CH₂—, X⁴ istrifluoromethyl.

In another group of compounds —B¹—B²—B³— is —C═N—CH₂—, X² is C—X⁶, Y¹,Y² and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl, ethyl,CH₃—O—CH₂—, cyclopropyl or cyclopropyl-CH₂—, preferably cyclopropyl, X⁴is trifluoromethyl.

In another group of compounds —B¹—B²—B³— is —C═N—CH₂—, Y¹, Y² and Y³ areC—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl, ethyl, CH₃—O—CH₂—,cyclopropyl or cyclopropyl-CH₂—, X⁴ is trifluoromethyl, X¹ is chloro, X²is CH, X³ is chloro or X¹ is trifluoromethyl, X² is CH, X³ istrifluoromethyl or X¹ is chloro, X² is C—Cl, X³ is chloro or X¹ ischloro, X² is CH, X³ is trifluoromethyl, or X¹ is chloro, X² is C—F, X³is chloro.

In another group of compounds —B¹—B²—B³— is —C═N—CH₂—, Y¹, Y², and Y³are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl, X¹ is chloro, X² isCH, X³ is chloro or X¹ is trifluoromethyl, X² is CH, X³ istrifluoromethyl or X¹ is chloro, X² is C—Cl, X³ is chloro or X¹ ischloro, X² is CH, X³ is trifluoromethyl, or X¹ is chloro, X² is C—F, X³is chloro.

In another group of compounds —B¹—B²—B³— is —C═N—CH₂—, Y¹, Y², and Y³are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is ethyl, X¹ is chloro, X² isCH, X³ is chloro or X¹ is trifluoromethyl, X² is CH, X³ istrifluoromethyl or X¹ is chloro, X² is C—Cl, X³ is chloro or X¹ ischloro, X² is CH, X³ is trifluoromethyl, or X¹ is chloro, X² is C—F, X³is chloro.

In another group of compounds —B¹—B²—B³— is —C═N—CH₂—, Y¹, Y², and Y³are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is CH₃—O—CH₂—, X¹ is chloro,X² is CH, X³ is chloro or X¹ is trifluoromethyl, X² is CH, X³ istrifluoromethyl or X¹ is chloro, X² is C—Cl, X³ is chloro or X¹ ischloro, X² is CH, X³ is trifluoromethyl, or X¹ is chloro, X² is C—F, X³is chloro.

In another group of compounds —B¹—B²—B³— is —C═N—CH₂—, Y¹, Y², and Y³are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is cyclopropyl, X¹ is chloro,X² is CH, X³ is chloro or X¹ is trifluoromethyl, X² is CH, X³ istrifluoromethyl or X¹ is chloro, X² is C—Cl, X³ is chloro or X¹ ischloro, X² is CH, X³ is trifluoromethyl, or X¹ is chloro, X² is C—F, X³is chloro.

In another group of compounds —B¹—B²—B³— is —C═N—CH₂—, Y¹, Y², and Y³are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is cyclopropyl-CH₂—, X¹ ischloro, X² is CH, X³ is chloro or X¹ is trifluoromethyl, X² is CH, X³ istrifluoromethyl or X¹ is chloro, X² is C—Cl, X³ is chloro or X¹ ischloro, X² is CH, X³ is trifluoromethyl, or X¹ is chloro, X² is C—F, X³is chloro.

In another group of compounds —B¹—B²—B³— is —C═N—CH₂—, Y¹, Y² and Y³ areC—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl, ethyl, CH₃—O—CH₂—,cyclopropyl or cyclopropyl-CH₂—, preferably cyclopropyl, X⁴ istrifluoromethyl, X¹ is chloro, X² is CH, X³ is chloro.

In another group of compounds —B¹—B²—B³— is —C═N—CH₂—, Y¹, Y² and Y³ areC—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl, ethyl, CH₃—O—CH₂—,cyclopropyl or cyclopropyl-CH₂—, preferably cyclopropyl, X⁴ istrifluoromethyl, X¹ is chloro, X² is C—Cl, X³ is chloro.

In another group of compounds —B¹—B²—B³— is —C═N—CH₂—, Y¹, Y² and Y³ areC—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl, ethyl, CH₃—O—CH₂—,cyclopropyl or cyclopropyl-CH₂—, preferably cyclopropyl, X⁴ istrifluoromethyl, X¹ is trifluoromethyl, X² is CH, X³ is trifluoromethyl.

In another group of compounds —B¹—B²—B³— is —C═N—CH₂—, Y¹, Y² and Y³ areC—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl, ethyl, CH₃—O—CH₂—,cyclopropyl or cyclopropyl-CH₂—, preferably cyclopropyl, X⁴ istrifluoromethyl, X¹ is chloro, X² is CH, X³ is trifluoromethyl.

In another group of compounds —B¹—B²—B³— is —C═N—CH₂—, Y¹, Y² and Y³ areC—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl, ethyl, CH₃—O—CH₂—,cyclopropyl or cyclopropyl-CH₂—, preferably cyclopropyl, X⁴ istrifluoromethyl, X¹ is chloro, X² is C—F, X³ is chloro. In another groupof compounds —B¹—B²—B³— is —C═N—CH₂—, X² is C—X⁶, Y¹, Y², and Y³ areC—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl.

In another group of compounds —B¹—B²—B³— is —C═N—CH₂—, X² is C—X⁶, Y¹,Y², and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is ethyl.

In another group of compounds —B¹—B²—B³— is —C═N—CH₂—, X² is C—X⁶, Y¹,Y², and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is CH₃—O—CH₂—.

In another group of compounds —B¹—B²—B³— is —C═N—CH₂—, X² is C—X⁶, Y¹,Y², and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is cyclopropyl.

In another group of compounds —B¹—B²—B³— is —C═N—CH₂—, X² is C—X⁶, Y¹,Y², and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ iscyclopropyl-CH₂—.

In another group of compounds —B¹—B²—B³— is —C═N—CH₂—, Y¹, Y², and Y³are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl and X¹ is chloro, X²is C—Cl, X³ is chloro or X¹ is chloro, X² is C—Cl, X³ is chloro or X¹ istrifluoromethyl, X² is CH, X³ is trifluoromethyl.

In another group of compounds —B¹—B²—B³— is —C═N—CH₂—, Y¹, Y², and Y³are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is ethyl and X¹ is chloro, X²is CH, X³ is chloro or X¹ is chloro, X² is C—Cl, X³ is chloro or X¹ istrifluoromethyl, X² is CH, X³ is trifluoromethyl.

In another group of compounds —B¹—B²—B³— is —C═N—CH₂—, Y¹, Y², and Y³are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is CH₃—O—CH₂— and X¹ ischloro, X² is CH, X³ is chloro or X¹ is chloro, X² is C—Cl, X³ is chloroor X¹ is trifluoromethyl, X² is CH, X³ is trifluoromethyl.

In another group of compounds —B¹—B²—B³— is —C═N—CH₂—, Y¹, Y², and Y³are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is cyclopropyl and X¹ ischloro, X² is CH, X³ is chloro or X¹ is chloro, X² is C—Cl, X³ is chloroor X¹ is trifluoromethyl, X² is CH, X³ is trifluoromethyl.

In another group of compounds —B¹—B²—B³— is —C═N—CH₂—, Y¹, Y², and Y³are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is cyclopropyl-CH₂— and X¹ ischloro, X² is CH, X³ is chloro or X¹ is chloro, X² is C—Cl, X³ is chloroor X¹ is trifluoromethyl, X² is CH, X³ is trifluoromethyl.

In a preferred group of compounds —B¹—B²—B³— is —N—CH₂—CH₂—, X² is C—X⁶,Y¹, Y², and Y³ are C—H, R⁵ is hydrogen, R⁸ is C₁-C₂alkyl,C₁-C₂alkyl-O—CH₂—, C₃-C₄cycloalkyl, or C₃-C₄cycloalkyl-CH₂—.

In another preferred group of compounds —B¹—B²—B³— is —N—CH₂—CH₂—, X² isC—X⁶, Y¹, Y², and Y³ are C—H, R⁵ is hydrogen, R⁸ is methyl, ethyl,CH₃—O—CH₂—, cyclopropyl or cyclopropyl-CH₂—, preferably cyclopropyl.

In another preferred group of compounds —B¹—B²—B³— is —N—CH₂—CH₂—, X² isC—X⁶, Y¹, Y² and Y³ are C—H, R⁵ is hydrogen, R⁸ is C₁-C₂alkyl,C₁-C₂alkyl-O—CH₂—, C₃-C₄cycloalkyl, or C₃-C₄cycloalkyl-CH₂—X⁴ istrifluoromethyl.

In another preferred group of compounds —B¹—B²—B³— is —N—CH₂—CH₂—, X² isC—X⁶, Y¹, Y², and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ isC₁-C₂alkyl, C₁-C₂alkyl-O—CH₂—, C₃-C₄cycloalkyl, or C₃-C₄cycloalkyl-CH₂—.

In another group of compounds —B¹—B²—B³— is —N—CH₂—CH₂—, X² is C—X⁶, Y¹,Y², and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl, ethyl,CH₃—O—CH₂—, cyclopropyl or cyclopropyl-CH₂—, preferably cyclopropyl.

In more preferred group of compounds —B¹—B²—B³— is —N—CH₂—CH₂—, X² isC—X⁶, Y¹, Y² and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ isC₁-C₂alkyl, C₁-C₂alkyl-O—CH₂—, C₃-C₄cycloalkyl, orC₃-C₄cycloalkyl-CH₂—X⁴ is trifluoromethyl.

In another more preferred group of compounds —B¹—B²—B³— is —N—CH₂—CH₂—,X² is C—X⁶, Y¹, Y², and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ ismethyl, ethyl, CH₃—O—CH₂—, cyclopropyl or cyclopropyl-CH₂—, X⁴ istrifluoromethyl.

In a very preferred group of compounds —B¹—B²—B³— is —N—CH₂—CH₂—, Y¹, Y²and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl, ethyl,CH₃—O—CH₂—, cyclopropyl or cyclopropyl-CH₂—, X⁴ is trifluoromethyl, X¹is chloro, X² is CH, X³ is chloro or X¹ is trifluoromethyl, X² is CH, X³is trifluoromethyl or X¹ is chloro, X² is C—Cl, X³ is chloro or X¹ ischloro, X² is CH, X³ is trifluoromethyl, or X¹ is chloro, X² is C—F, X³is chloro.

In another very preferred group of compounds —B¹—B²—B³— is —N—CH₂—CH₂—,Y¹, Y², and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl, X¹is chloro, X² is CH, X³ is chloro or X¹ is trifluoromethyl, X² is CH, X³is trifluoromethyl or X¹ is chloro, X² is C—Cl, X³ is chloro or X¹ ischloro, X² is CH, X³ is trifluoromethyl, or X¹ is chloro, X² is C—F, X³is chloro.

In another very preferred group of compounds —B¹—B²—B³— is —N—CH₂—CH₂—,Y¹, Y², and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is ethyl, X¹ ischloro, X² is CH, X³ is chloro or X¹ is trifluoromethyl, X² is CH, X³ istrifluoromethyl or X¹ is chloro, X² is C—Cl, X³ is chloro or X¹ ischloro, X² is CH, X³ is trifluoromethyl, or X¹ is chloro, X² is C—F, X³is chloro.

In another very preferred group of compounds —B¹—B²—B³— is —N—CH₂—CH₂—,Y¹, Y², and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is CH₃—O—CH₂—,X¹ is chloro, X² is CH, X³ is chloro or X¹ is trifluoromethyl, X² is CH,X³ is trifluoromethyl or X¹ is chloro, X² is C—Cl, X³ is chloro or X¹ ischloro, X² is CH, X³ is trifluoromethyl, or X¹ is chloro, X² is C—F, X³is chloro.

In another very preferred group of compounds —B¹—B²—B³— is —N—CH₂—CH₂—,Y¹, Y², and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is cyclopropyl,X¹ is chloro, X² is CH, X³ is chloro or X¹ is trifluoromethyl, X² is CH,X³ is trifluoromethyl or X¹ is chloro, X² is C—Cl, X³ is chloro or X¹ ischloro, X² is CH, X³ is trifluoromethyl, or X¹ is chloro, X² is C—F, X³is chloro.

In another very preferred group of compounds —B¹—B²—B³— is —N—CH₂—CH₂—,Y¹, Y², and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ iscyclopropyl-CH₂—, X¹ is chloro, X² is CH, X³ is chloro or X¹ istrifluoromethyl, X² is CH, X³ is trifluoromethyl or X¹ is chloro, X² isC—Cl, X³ is chloro or X¹ is chloro, X² is CH, X³ is trifluoromethyl, orX¹ is chloro, X² is C—F, X³ is chloro.

In another very preferred group of compounds —B¹—B²—B³— is —N—CH₂—CH₂—,Y¹, Y² and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl,ethyl, CH₃—O—CH₂—, cyclopropyl or cyclopropyl-CH₂—, preferablycyclopropryl, X⁴ is trifluoromethyl, X¹ is chloro, X² is CH, X³ ischloro.

In another very preferred group of compounds —B¹—B²—B³— is —N—CH₂—CH₂—,Y¹, Y² and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl,ethyl, CH₃—O—CH₂—, cyclopropyl or cyclopropyl-CH₂—, preferablycyclopropryl, X⁴ is trifluoromethyl, X¹ is chloro, X² is C—Cl, X³ ischloro.

In another very preferred group of compounds —B¹—B²—B³— is —N—CH₂—CH₂—,Y¹, Y² and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl,ethyl, CH₃—O—CH₂—, cyclopropyl or cyclopropyl-CH₂—, preferablycyclopropryl, X⁴ is trifluoromethyl, X¹ is trifluoromethyl, X² is CH, X³is trifluoromethyl.

In another very preferred group of compounds —B¹—B²—B³— is —N—CH₂—CH₂—,Y¹, Y² and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl,ethyl, CH₃—O—CH₂—, cyclopropyl or cyclopropyl-CH₂—, preferablycyclopropryl, X⁴ is trifluoromethyl, X¹ is chloro, X² is CH, X³ istrifluoromethyl.

In another very preferred group of compounds —B¹—B²—B³— is —N—CH₂—CH₂—,Y¹, Y² and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl,ethyl, CH₃—O—CH₂—, cyclopropyl or cyclopropyl-CH₂—, preferablycyclopropryl, X⁴ is trifluoromethyl, X¹ is chloro, X² is C—F, X³ ischloro.

In another very preferred group of compounds —B¹—B²—B³— is —N—CH₂—CH₂—,X² is C—X⁶, Y¹, Y², and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ ismethyl.

In another group of compounds —B¹—B²—B³— is —N—CH₂—CH₂—, X² is C—X⁶, Y¹,Y², and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is ethyl.

In another very preferred group of compounds —B¹—B²—B³— is —N—CH₂—CH₂—,X² is C—X⁶, Y¹, Y², and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ isCH₃—O—CH₂—.

In another very preferred group of compounds —B¹—B²—B³— is —N—CH₂—CH₂—,X² is C—X⁶, Y¹, Y², and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ iscyclopropyl.

In another group of compounds —B¹—B²—B³— is —N—CH₂—CH₂—, X² is C—X⁶, Y¹,Y², and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ iscyclopropyl-CH₂—.

In another very preferred group of compounds —B¹—B²—B³— is —N—CH₂—CH₂—,Y¹, Y², and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl andX¹ is chloro, X² is CH, X³ is chloro or X¹ is chloro, X² is C—Cl, X³ ischloro or X¹ is trifluoromethyl, X² is CH, X³ is trifluoromethyl.

In another very preferred group of compounds —B¹—B²—B³— is —N—CH₂—CH₂—,Y¹, Y², and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is ethyl and X¹is chloro, X² is CH, X³ is chloro or X¹ is chloro, X² is C—Cl, X³ ischloro or X¹ is trifluoromethyl, X² is CH, X³ is trifluoromethyl.

In another very preferred group of compounds —B¹—B²—B³— is —N—CH₂—CH₂—,Y¹, Y², and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is CH₃—O—CH₂—and X¹ is chloro, X² is CH, X³ is chloro or X¹ is chloro, X² is C—Cl, X³is chloro or X¹ is trifluoromethyl, X² is CH, X³ is trifluoromethyl.

In another very preferred group of compounds —B¹—B²—B³— is —N—CH₂—CH₂—,Y¹, Y², and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is cyclopropyland X¹ is chloro, X² is CH, X³ is chloro or X¹ is chloro, X² is C—Cl, X³is chloro or X¹ is trifluoromethyl, X² is CH, X³ is trifluoromethyl.

In another very preferred group of compounds —B¹—B²—B³— is —N—CH₂—CH₂—,Y¹, Y², and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ iscyclopropyl-CH₂— and X¹ is chloro, X² is CH, X³ is chloro or X¹ ischloro, X² is C—Cl, X³ is chloro or X¹ is trifluoromethyl, X² is CH, X³is trifluoromethyl.

In another group of compounds —B¹—B²—B³— is —C═N—O—, X² is C—X⁶, Y¹, Y²,and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is C₁-C₂alkyl,C₁-C₂alkyl-O—CH₂—, C₃-C₄cycloalkyl, or C₃-C₄cycloalkyl-CH₂—.

In another group of compounds —B¹—B²—B³— is —C═N—O—, X² is C—X⁶, Y¹, Y²,and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl, ethyl,CH₃—O—CH₂—, cyclopropyl or cyclopropyl-CH₂—, preferably cyclopropyl.

In another group of compounds —B¹—B²—B³— is —C═N—O—, X² is C—X⁶, Y¹, Y²and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is C₁-C₂alkyl,C₁-C₂alkyl-O—CH₂—, C₃-C₄cycloalkyl, or C₃-C₄cycloalkyl-CH₂—X⁴ istrifluoromethyl.

In another group of compounds —B¹—B²—B³— is —C═N—O—, X² is C—X⁶, Y¹, Y²,and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is C₁-C₂alkyl,C₁-C₂alkyl-O—CH₂—, C₃-C₄cycloalkyl, or C₃-C₄cycloalkyl-CH₂—.

In another group of compounds —B¹—B²—B³— is —C═N—O—, X² is C—X⁶, Y¹, Y²,and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl, ethyl,CH₃—O—CH₂—, cyclopropyl or cyclopropyl-CH₂—, preferably cyclopropyl.

In another group of compounds —B¹—B²—B³— is —C═N—O—, X² is C—X⁶, Y¹, Y²and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is C₁-C₂alkyl,C₁-C₂alkyl-O—CH₂—, C₃-C₄cycloalkyl, or C₃-C₄cycloalkyl-CH₂—, X⁴ istrifluoromethyl.

In another group of compounds —B¹—B²—B³— is —C═N—O—, X² is C—X⁶, Y¹, Y²and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl, ethyl,CH₃—O—CH₂—, cyclopropyl or cyclopropyl-CH₂—, X⁴ is trifluoromethyl.

In another group of compounds —B¹—B²—B³— is —C═N—O—, Y¹, Y² and Y³ areC—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl, ethyl, CH₃—O—CH₂—,cyclopropyl or cyclopropyl-CH₂—, X⁴ is trifluoromethyl, X¹ is chloro, X²is CH, X³ is chloro or X¹ is trifluoromethyl, X² is CH, X³ istrifluoromethyl or X¹ is chloro, X² is C—Cl, X³ is chloro or X¹ ischloro, X² is CH, X³ is trifluoromethyl, or X¹ is chloro, X² is C—F, X³is chloro.

In another group of compounds —B¹—B²—B³— is —C═N—O—, Y¹, Y², and Y³ areC—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl, X¹ is chloro, X² is CH,X³ is chloro or X¹ is trifluoromethyl, X² is CH, X³ is trifluoromethylor X¹ is chloro, X² is C—Cl, X³ is chloro or X¹ is chloro, X² is CH, X³is trifluoromethyl, or X¹ is chloro, X² is C—F, X³ is chloro.

In another group of compounds —B¹—B²—B³— is —C═N—O—, Y¹, Y², and Y³ areC—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is ethyl, X¹ is chloro, X² is CH,X³ is chloro or X¹ is trifluoromethyl, X² is CH, X³ is trifluoromethylor X¹ is chloro, X² is C—Cl, X³ is chloro or X¹ is chloro, X² is CH, X³is trifluoromethyl, or X¹ is chloro, X² is C—F, X³ is chloro.

In another group of compounds —B¹—B²—B³— is —C═N—O—, Y¹, Y², and Y³ areC—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is CH₃—O—CH₂—, X¹ is chloro, X² isCH, X³ is chloro or X¹ is trifluoromethyl, X² is CH, X³ istrifluoromethyl or X¹ is chloro, X² is C—Cl, X³ is chloro or X¹ ischloro, X² is CH, X³ is trifluoromethyl, or X¹ is chloro, X² is C—F, X³is chloro.

In another group of compounds —B¹—B²—B³— is —C═N—O—, Y¹, Y², and Y³ areC—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is cyclopropyl, X¹ is chloro, X²is CH, X³ is chloro or X¹ is trifluoromethyl, X² is CH, X³ istrifluoromethyl or X¹ is chloro, X² is C—Cl, X³ is chloro or X¹ ischloro, X² is CH, X³ is trifluoromethyl, or X¹ is chloro, X² is C—F, X³is chloro.

In another group of compounds —B¹—B²—B³— is —C═N—O—, Y¹, Y², and Y³ areC—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is cyclopropyl-CH₂—, X¹ is chloro,X² is CH, X³ is chloro or X¹ is trifluoromethyl, X² is CH, X³ istrifluoromethyl or X¹ is chloro, X² is C—Cl, X³ is chloro or X¹ ischloro, X² is CH, X³ is trifluoromethyl, or X¹ is chloro, X² is C—F, X³is chloro.

In another group of compounds —B¹—B²—B³— is —C═N—O—, Y¹, Y² and Y³ areC—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl, ethyl, CH₃—O—CH₂—,cyclopropyl or cyclopropyl-CH₂—, preferably cyclopropyl, X⁴ istrifluoromethyl, X¹ is chloro, X² is CH, X³ is chloro.

In another group of compounds —B¹—B²—B³— is —C═N—O—, Y¹, Y² and Y³ areC—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl, ethyl, CH₃—O—CH₂—,cyclopropyl or cyclopropyl-CH₂—, preferably cyclopropyl, X⁴ istrifluoromethyl, X¹ is chloro, X² is C—Cl, X³ is chloro.

In another group of compounds —B¹—B²—B³— is —C═N—O—, Y¹, Y² and Y³ areC—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl, ethyl, CH₃—O—CH₂—,cyclopropyl or cyclopropyl-CH₂—, preferably cyclopropyl, X⁴ istrifluoromethyl, X¹ is trifluoromethyl, X² is CH, X³ is trifluoromethyl.

In another group of compounds —B¹—B²—B³— is —C═N—O—, Y¹, Y² and Y³ areC—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl, ethyl, CH₃—O—CH₂—,cyclopropyl or cyclopropyl-CH₂—, preferably cyclopropyl, X⁴ istrifluoromethyl, X¹ is chloro, X² is CH, X³ is trifluoromethyl

In another group of compounds —B¹—B²—B³— is —C═N—O—, Y¹, Y² and Y³ areC—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl, ethyl, CH₃—O—CH₂—,cyclopropyl or cyclopropyl-CH₂—, preferably cyclopropyl, X⁴ istrifluoromethyl, X¹ is chloro, X² is C—F, X³ is chloro.

In another group of compounds —B¹—B²—B³— is —C═N—O—, X² is C—X⁶, Y¹, Y²,and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl.

In another group of compounds —B¹—B²—B³— is —C═N—O—, X² is C—X⁶, Y¹, Y²,and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is ethyl.

In another group of compounds —B¹—B²—B³— is —C═N—O—, X² is C—X⁶, Y¹, Y²,and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is CH₃—O—CH₂—.

In another group of compounds —B¹—B²—B³— is —C═N—O—, X² is C—X⁶, Y¹, Y²,and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is cyclopropyl.

In another group of compounds —B¹—B²—B³— is —C═N—O—, X² is C—X⁶, Y¹, Y²,and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is cyclopropyl-CH₂—.

In another group of compounds —B¹—B²—B³— is —C═N—O—, Y¹, Y², and Y³ areC—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is methyl and X¹ is chloro, X² isCH, X³ is chloro or X¹ is chloro, X² is C—Cl, X³ is chloro or X¹ istrifluoromethyl, X² is CH, X³ is trifluoromethyl.

In another group of compounds —B¹—B²—B³— is —C═N—O—, Y¹, Y², and Y³ areC—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is ethyl and X¹ is chloro, X² isCH, X³ is chloro or X¹ is chloro, X² is C—Cl, X³ is chloro or X¹ istrifluoromethyl, X² is CH, X³ is trifluoromethyl.

In another group of compounds —B¹—B²—B³— is —C═N—O—, Y¹, Y², and Y³ areC—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is CH₃—O—CH₂— and X¹ is chloro, X²is CH, X³ is chloro or X¹ is chloro, X² is C—Cl, X³ is chloro or X¹ istrifluoromethyl, X² is CH, X³ is trifluoromethyl.

In another group of compounds —B¹—B²—B³— is —C═N—O—, Y¹, Y², and Y³ areC—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is cyclopropyl and X¹ is chloro,X² is CH, X³ is chloro or X¹ is chloro, X² is C—Cl, X³ is chloro or X¹is trifluoromethyl, X² is CH, X³ is trifluoromethyl.

In another group of compounds —B¹—B²—B³— is —C═N—O—, Y¹, Y², and Y³ areC—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is cyclopropyl-CH₂— and X¹ ischloro, X² is CH, X³ is chloro or X¹ is chloro, X² is C—Cl, X³ is chloroor X¹ is trifluoromethyl, X² is CH, X³ is trifluoromethyl.

Due to a stereocentre compounds of formula I include may exist ascompounds of formula I* or compounds of formula I**.

Compounds of formula I** are more biologically active than compounds offormula I* and are preferred. The compound of formula I may be a mixtureof compounds I* and I** in any ratio e.g. in a molar ratio of 1:99 to99:1, e.g. 10:1 to 1:10, e.g. a substantially 50:50 molar ratio.Preferably the compound of formula I is a racemic mixture of thecompounds of formula I** and I* or is enantiomerically enriched for thecompound of formula I**. For example, when the compound of formula I isan enantiomerically enriched mixture of formula I**, the molarproportion of compound I** compared to the total amount of bothenantiomers is for example greater than 50%, e.g. at least 55, 60, 65,70, 75, 80, 85, 90, 95, 96, 97, 98, or at least 99%. Preferably thecompound of formula I is at least 90% enriched for the compound offormula I**.

In one embodiment component A is a compound of formula I** insubstantially pure form, e.g. it is provided substantially in theabsence of the alternative enantiomer. Enantio-enriched mixtures of theinvention do not contain any compounds of formula I in addition tocomponent A. In other words, the molar amount of compound of formula I**in the enantio-enriched mixtures of the invention is greater than themolar amount of the compounds of formula I*.

The invention also provides mixtures consisting of component A andcomponent B in addition to customary formulation ingredients, e.g. anagriculturally acceptable carrier and optionally a surfactant.

Due to an additional chiral centre compounds of formula I may exist ascompounds of formula I-a or I-b

Compounds of formula I-b are preferred. The compound of formula I may bea mixture of compounds I-a and I-b in any ratio e.g. in a molar ratio of1:99 to 99:1, e.g. 10:1 to 1:10, e.g. a substantially 50:50 molar ratio.Preferably the compound of formula I is a racemic mixture of thecompounds of formula I-a and I-b or is enantiomerically enriched for thecompound of formula I-b. For example, when the compound of formula I isan enantiomerically enriched mixture of formula I-b, the molarproportion of compound I-b compared to the total amount of bothenantiomers is for example greater than 50%, e.g. at least 55, 60, 65,70, 75, 80, 85, 90, 95, 96, 97, 98, or at least 99%. Preferably thecompound of formula I is at least 90% enriched for the compound offormula I-b.

Thus compounds of formula I may exist as compounds of formula I*-a,I**-a, I*-b and I**-b

Compounds of formula I**-b are preferred. Preferably the compound offormula I is a racemic mixture of the compounds of formula I*-a, I**-a,I*-b and I**-b or is enantiomerically enriched for the compound offormula I**-b. For example, when the compound of formula I is anenantiomerically enriched mixture of formula I**-b, the molar proportionof compound I**-b compared to the total amount of the four enantiomersis for example greater than 25%, e.g. at least 30, 35, 40, 45, 50, 55,60, 65, 70, 75, 80, 85, 90, 95, 96, 97, 98, or at least 99%.

A selection of preferred compounds of formula I are the compoundsdepicted in the tables below. The symbol * indicates the location of thechiral centre. I** refers to a compound of formula I**.

TABLE A Compounds of formula Ia (Ia)

Comp Stereochemistry No. at * X1 X2 X3 R⁸  1 racemic mixture Cl C—Cl Clmethyl  2 racemic mixture Cl C—Cl Cl ethyl  3 racemic mixture Cl C—Cl Clcyclopropyl  4 racemic mixture Cl C—Cl Cl CH₃O—CH₂—  5 racemic mixtureCl C—Cl Cl cyclopropyl- CH₂—  6 racemic mixture Cl C—Cl Cl isopropyl  7racemic mixture Cl C—H Cl methyl  8 racemic mixture Cl C—H Cl ethyl  9racemic mixture Cl C—H Cl cyclopropyl 10 racemic mixture Cl C—H ClCH₃O—CH₂— 11 racemic mixture Cl C—H Cl cyclopropyl- CH₂— 12 racemicmixture Cl C—H Cl isopropyl 13 racemic mixture CF₃ C—H CF₃ methyl 14racemic mixture CF₃ C—H CF₃ ethyl 15 racemic mixture CF₃ C—H CF₃cyclopropyl 16 racemic mixture CF₃ C—H CF₃ CH₃O—CH₂— 17 racemic mixtureCF₃ C—H CF₃ cyclopropyl- CH₂— 18 racemic mixture CF₃ C—H CF₃ isopropyl19 racemic mixture Cl C—H CF₃ methyl 20 racemic mixture Cl C—H CF₃ ethyl21 racemic mixture Cl C—H CF₃ cyclopropyl 22 racemic mixture Cl C—H CF₃CH₃O—CH₂— 23 racemic mixture Cl C—H CF₃ cyclopropyl- CH₂— 24 racemicmixture Cl C—H CF₃ isopropyl 25 racemic mixture Br C—H CF₃ methyl 26racemic mixture Br C—H CF₃ ethyl 27 racemic mixture Br C—H CF₃cyclopropyl 28 racemic mixture Br C—H CF₃ CH₃O—CH₂— 29 racemic mixtureBr C—H CF₃ cyclopropyl- CH₂— 30 racemic mixture Br C—H CF₃ isopropyl 31as for I** Cl C—Cl Cl methyl 32 as for I** Cl C—Cl Cl ethyl 33 as forI** Cl C—Cl Cl cyclopropyl 34 as for I** Cl C—Cl Cl CH₃O—CH₂— 35 as forI** Cl C—Cl Cl cyclopropyl- CH₂— 36 as for I** Cl C—Cl Cl isopropyl 37as for I** Cl C—H Cl methyl 38 as for I** Cl C—H Cl ethyl 39 as for I**Cl C—H Cl cyclopropyl 40 as for I** Cl C—H Cl CH₃O—CH₂— 41 as for I** ClC—H Cl cyclopropyl- CH₂— 42 as for I** Cl C—H Cl isopropyl 43 as for I**CF₃ C—H CF₃ methyl 44 as for I** CF₃ C—H CF₃ ethyl 45 as for I** CF₃ C—HCF₃ cyclopropyl 46 as for I** CF₃ C—H CF₃ CH₃O—CH₂— 47 as for I** CF₃C—H CF₃ cyclopropyl- CH₂— 48 as for I** CF₃ C—H CF₃ isopropyl 49 as forI** Cl C—H CF₃ methyl 50 as for I** Cl C—H CF₃ ethyl 51 as for I** ClC—H CF₃ cyclopropyl 52 as for I** Cl C—H CF₃ CH₃O—CH₂— 53 as for I** ClC—H CF₃ cyclopropyl- CH₂— 54 as for I** Cl C—H CF₃ isopropyl 55 as forI** Br C—H CF₃ methyl 56 as for I** Br C—H CF₃ ethyl 57 as for I** BrC—H CF₃ cyclopropyl 58 as for I** Br C—H CF₃ CH₃O—CH₂— 59 as for I** BrC—H CF₃ cyclopropyl- CH₂— 60 as for I** Br C—H CF₃ isopropyl

TABLE B Compounds of formula Ib (Ib)

Comp Stereochemistry No. at * X1 X2 X3 R⁸  1 racemic mixture Cl C—Cl Clmethyl  2 racemic mixture Cl C—Cl Cl ethyl  3 racemic mixture Cl C—Cl Clcyclopropyl  4 racemic mixture Cl C—Cl Cl CH₃O—CH₂—  5 racemic mixtureCl C—Cl Cl cyclopropyl-CH₂—  6 racemic mixture Cl C—Cl Cl isopropyl  7racemic mixture Cl C—H Cl methyl  8 racemic mixture Cl C—H Cl ethyl  9racemic mixture Cl C—H Cl cyclopropyl 10 racemic mixture Cl C—H ClCH₃O—CH₂— 11 racemic mixture Cl C—H Cl cyclopropyl-CH₂— 12 racemicmixture Cl C—H Cl isopropyl 13 racemic mixture CF₃ C—H CF₃ methyl 14racemic mixture CF₃ C—H CF₃ ethyl 15 racemic mixture CF₃ C—H CF₃cyclopropyl 16 racemic mixture CF₃ C—H CF₃ CH₃O—CH₂— 17 racemic mixtureCF₃ C—H CF₃ cyclopropyl-CH₂— 18 racemic mixture CF₃ C—H CF₃ isopropyl 19racemic mixture Cl C—H CF₃ methyl 20 racemic mixture Cl C—H CF₃ ethyl 21racemic mixture Cl C—H CF₃ cyclopropyl 22 racemic mixture Cl C—H CF₃CH₃O—CH₂— 23 racemic mixture Cl C—H CF₃ cyclopropyl-CH₂— 24 racemicmixture Cl C—H CF₃ isopropyl 25 racemic mixture Br C—H CF₃ methyl 26racemic mixture Br C—H CF₃ ethyl 27 racemic mixture Br C—H CF₃cyclopropyl 28 racemic mixture Br C—H CF₃ CH₃O—CH₂— 29 racemic mixtureBr C—H CF₃ cyclopropyl-CH₂— 30 racemic mixture Br C—H CF₃ isopropyl 31as for I** Cl C—Cl Cl methyl 32 as for I** Cl C—Cl Cl ethyl 33 as forI** Cl C—Cl Cl cyclopropyl 34 as for I** Cl C—Cl Cl CH₃O—CH₂— 35 as forI** Cl C—Cl Cl cyclopropyl-CH₂— 36 as for I** Cl C—Cl Cl isopropyl 37 asfor I** Cl C—H Cl methyl 38 as for I** Cl C—H Cl ethyl 39 as for I** ClC—H Cl cyclopropyl 40 as for I** Cl C—H Cl CH₃O—CH₂— 41 as for I** ClC—H Cl cyclopropyl-CH₂— 42 as for I** Cl C—H Cl isopropyl 43 as for I**CF₃ C—H CF₃ methyl 44 as for I** CF₃ C—H CF₃ ethyl 45 as for I** CF₃ C—HCF₃ cyclopropyl 46 as for I** CF₃ C—H CF₃ CH₃O—CH₂— 47 as for I** CF₃C—H CF₃ cyclopropyl-CH₂— 48 as for I** CF₃ C—H CF₃ isopropyl 49 as forI** Cl C—H CF₃ methyl 50 as for I** Cl C—H CF₃ ethyl 51 as for I** ClC—H CF₃ cyclopropyl 52 as for I** Cl C—H CF₃ CH₃O—CH₂— 53 as for I** ClC—H CF₃ cyclopropyl-CH₂— 54 as for I** Cl C—H CF₃ isopropyl 55 as forI** Br C—H CF₃ methyl 56 as for I** Br C—H CF₃ ethyl 57 as for I** BrC—H CF₃ cyclopropyl 58 as for I** Br C—H CF₃ CH₃O—CH₂— 59 as for I** BrC—H CF₃ cyclopropyl-CH₂— 60 as for I** Br C—H CF₃ isopropyl

TABLE C Compounds of formula Ic

Comp Stereochemistry No. at * X1 X2 X3 R8  1 racemic mixture Cl C—Cl Clmethyl  2 racemic mixture Cl C—Cl Cl ethyl  3 racemic mixture Cl C—Cl Clcyclopropyl  4 racemic mixture Cl C—Cl Cl CH₃O—CH₂—  5 racemic mixtureCl C—Cl Cl cyclopropyl-CH₂—  6 racemic mixture Cl C—Cl Cl isopropyl  7racemic mixture Cl C—H Cl methyl  8 racemic mixture Cl C—H Cl ethyl  9racemic mixture Cl C—H Cl cyclopropyl 10 racemic mixture Cl C—H ClCH₃O—CH₂— 11 racemic mixture Cl C—H Cl cyclopropyl-CH₂— 12 racemicmixture Cl C—H Cl isopropyl 13 racemic mixture CF₃ C—H CF₃ methyl 14racemic mixture CF₃ C—H CF₃ ethyl 15 racemic mixture CF₃ C—H CF₃cyclopropyl 16 racemic mixture CF₃ C—H CF₃ CH₃O—CH₂— 17 racemic mixtureCF₃ C—H CF₃ cyclopropyl-CH₂— 18 racemic mixture CF₃ C—H CF₃ isopropyl 19racemic mixture Cl C—H CF₃ methyl 20 racemic mixture Cl C—H CF₃ ethyl 21racemic mixture Cl C—H CF₃ cyclopropyl 22 racemic mixture Cl C—H CF₃CH₃O—CH₂— 23 racemic mixture Cl C—H CF₃ cyclopropyl-CH₂— 24 racemicmixture Cl C—H CF₃ isopropyl 25 racemic mixture Br C—H CF₃ methyl 26racemic mixture Br C—H CF₃ ethyl 27 racemic mixture Br C—H CF₃cyclopropyl 28 racemic mixture Br C—H CF₃ CH₃O—CH₂— 29 racemic mixtureBr C—H CF₃ cyclopropyl-CH₂— 30 racemic mixture Br C—H CF₃ isopropyl 31as for I** Cl C—Cl Cl methyl 32 as for I** Cl C—Cl Cl ethyl 33 as forI** Cl C—Cl Cl cyclopropyl 34 as for I** Cl C—Cl Cl CH₃O—CH₂— 35 as forI** Cl C—Cl Cl cyclopropyl-CH₂— 36 as for I** Cl C—Cl Cl isopropyl 37 asfor I** Cl C—H Cl methyl 38 as for I** Cl C—H Cl ethyl 39 as for I** ClC—H Cl cyclopropyl 40 as for I** Cl C—H Cl CH₃O—CH₂— 41 as for I** ClC—H Cl cyclopropyl-CH₂— 42 as for I** Cl C—H Cl isopropyl 43 as for I**CF₃ C—H CF₃ methyl 44 as for I** CF₃ C—H CF₃ ethyl 45 as for I** CF₃ C—HCF₃ cyclopropyl 46 as for I** CF₃ C—H CF₃ CH₃O—CH₂— 47 as for I** CF₃C—H CF₃ cyclopropyl-CH₂— 48 as for I** CF₃ C—H CF₃ isopropyl 49 as forI** Cl C—H CF₃ methyl 50 as for I** Cl C—H CF₃ ethyl 51 as for I** ClC—H CF₃ cyclopropyl 52 as for I** Cl C—H CF₃ CH₃O—CH₂— 53 as for I** ClC—H CF₃ cyclopropyl-CH₂— 54 as for I** Cl C—H CF₃ isopropyl 55 as forI** Br C—H CF₃ methyl 56 as for I** Br C—H CF₃ ethyl 57 as for I** BrC—H CF₃ cyclopropyl 58 as for I** Br C—H CF₃ CH₃O—CH₂— 59 as for I** BrC—H CF₃ cyclopropyl-CH₂— 60 as for I** Br C—H CF₃ isopropyl

TABLE D Compounds of formula Id (Id)

Stereo- Comp chemistry No. at * X1 X2 X3 R⁵ R⁸  1 racemic Cl C—Cl Cl Clmethyl mixture  2 racemic Cl C—Cl Cl Cl ethyl mixture  3 racemic Cl C—ClCl Cl cyclopropyl mixture  4 racemic Cl C—Cl Cl Cl CH₃O—CH₂— mixture  5racemic Cl C—Cl Cl Cl cyclopropyl-CH₂— mixture  6 racemic Cl C—Cl Cl Clisopropyl mixture  7 racemic Cl C—Cl Cl Cl CH₃S—CH₂— mixture  8 racemicCl C—Cl Cl Cl CH₃SO₂—CH₂— mixture  9 racemic Cl C—Cl Cl Cl CF₃—CH₂—mixture  10 racemic Cl C—H Cl Cl methyl mixture  11 racemic Cl C—H Cl Clethyl mixture  12 racemic Cl C—H Cl Cl cyclopropyl mixture  13 racemicCl C—H Cl Cl CH₃O—CH₂— mixture  14 racemic Cl C—H Cl Cl cyclopropyl-CH₂—mixture  15 racemic Cl C—H Cl Cl CH₃S—CH₂— mixture  16 racemic Cl C—H ClCl CH₃SO₂—CH₂— mixture  17 racemic Cl C—H Cl Cl CF₃—CH₂— mixture  18racemic Cl C—H Cl Cl isopropyl mixture  19 racemic CF₃ C—H CF₃ Cl methylmixture  20 racemic CF₃ C—H CF₃ Cl ethyl mixture  21 racemic CF₃ C—H CF₃Cl cyclopropyl mixture  22 racemic CF₃ C—H CF₃ Cl CH₃O—CH₂— mixture  23racemic CF₃ C—H CF₃ Cl cyclopropyl-CH₂— mixture  24 racemic CF₃ C—H CF₃Cl CH₃S—CH₂— mixture  25 racemic CF₃ C—H CF₃ Cl CH₃SO₂—CH₂— mixture  26racemic CF₃ C—H CF₃ Cl CF₃—CH₂— mixture  27 racemic CF₃ C—H CF₃ Clisopropyl mixture  28 racemic Cl C—H CF₃ Cl methyl mixture  29 racemicCl C—H CF₃ Cl ethyl mixture  30 racemic Cl C—H CF₃ Cl cyclopropylmixture  31 racemic Cl C—H CF₃ Cl CH₃O—CH₂— mixture  32 racemic Cl C—HCF₃ Cl cyclopropyl-CH₂— mixture  33 racemic Cl C—H CF₃ Cl CH₃S—CH₂—mixture  34 racemic Cl C—H CF₃ Cl CH₃SO₂—CH₂— mixture  35 racemic Cl C—HCF₃ Cl CF₃—CH₂— mixture  36 racemic Cl C—H CF₃ Cl isopropyl mixture  37racemic Br C—H CF₃ Cl methyl mixture  38 racemic Br C—H CF₃ Cl ethylmixture  39 racemic Br C—H CF₃ Cl cyclopropyl mixture  40 racemic Br C—HCF₃ Cl CH₃O—CH₂— mixture  41 racemic Br C—H CF₃ Cl cyclopropyl-CH₂—mixture  42 racemic Br C—H CF₃ Cl CH₃S—CH₂— mixture  43 racemic Br C—HCF₃ Cl CH₃SO₂—CH₂— mixture  44 racemic Br C—H CF₃ Cl CF₃—CH₂— mixture 45 racemic Br C—H CF₃ Cl isopropyl mixture  46 as for I** Cl C—Cl Cl Clmethyl  47 as for I** Cl C—Cl Cl Cl ethyl  48 as for I** Cl C—Cl Cl Clcyclopropyl  49 as for I** Cl C—Cl Cl Cl CH₃O—CH₂—  50 as for I** ClC—Cl Cl Cl cyclopropyl-CH₂—  51 as for I** Cl C—Cl Cl Cl isopropyl  52as for I** Cl C—Cl Cl Cl CH₃S—CH₂—  53 as for I** Cl C—Cl Cl ClCH₃SO₂—CH₂—  54 as for I** Cl C—Cl Cl Cl CF₃—CH₂—  55 as for I** Cl C—HCl Cl methyl  56 as for I** Cl C—H Cl Cl ethyl  57 as for I** Cl C—H ClCl cyclopropyl  58 as for I** Cl C—H Cl Cl CH₃O—CH₂—  59 as for I** ClC—H Cl Cl cyclopropyl-CH₂—  60 as for I** Cl C—H Cl Cl CH₃S—CH₂—  61 asfor I** Cl C—H Cl Cl CH₃SO₂—CH₂—  62 as for I** Cl C—H Cl Cl CF₃—CH₂— 63 as for I** Cl C—H Cl Cl isopropyl  64 as for I** CF₃ C—H CF₃ Clmethyl  65 as for I** CF₃ C—H CF₃ Cl ethyl  66 as for I** CF₃ C—H CF₃ Clcyclopropyl  67 as for I** CF₃ C—H CF₃ Cl CH₃O—CH₂—  68 as for I** CF₃C—H CF₃ Cl cyclopropyl-CH₂—  69 as for I** CF₃ C—H CF₃ Cl CH₃S—CH₂—  70as for I** CF₃ C—H CF₃ Cl CH₃SO₂—CH₂—  71 as for I** CF₃ C—H CF₃ ClCF₃—CH₂—  72 as for I** CF₃ C—H CF₃ Cl isopropyl  73 as for I** Cl C—HCF₃ Cl methyl  74 as for I** Cl C—H CF₃ Cl ethyl  75 as for I** Cl C—HCF₃ Cl cyclopropyl  76 as for I** Cl C—H CF₃ Cl CH₃O—CH₂—  77 as for I**Cl C—H CF₃ Cl cyclopropyl-CH₂—  78 as for I** Cl C—H CF₃ Cl CH₃S—CH₂— 79 as for I** Cl C—H CF₃ Cl CH₃SO₂—CH₂—  80 as for I** Cl C—H CF₃ ClCF₃—CH₂—  81 as for I** Cl C—H CF₃ Cl isopropyl  82 as for I** Br C—HCF₃ Cl methyl  83 as for I** Br C—H CF₃ Cl ethyl  84 as for I** Br C—HCF₃ Cl cyclopropyl  85 as for I** Br C—H CF₃ Cl CH₃O—CH₂—  86 as for I**Br C—H CF₃ Cl cyclopropyl-CH₂—  87 as for I** Br C—H CF₃ Cl CH₃S—CH₂— 88 as for I** Br C—H CF₃ Cl CH₃SO₂—CH₂—  89 as for I** Br C—H CF₃ ClCF₃—CH₂—  90 as for I** Br C—H CF₃ Cl isopropyl  91 racemic Cl C—Cl ClCH₃ methyl mixture  92 racemic Cl C—Cl Cl CH₃ ethyl mixture  93 racemicCl C—Cl Cl CH₃ cyclopropyl mixture  94 racemic Cl C—Cl Cl CH₃ CH₃O—CH₂—mixture  95 racemic Cl C—Cl Cl CH₃ cyclopropyl-CH₂— mixture  96 racemicCl C—Cl Cl CH₃ isopropyl mixture  97 racemic Cl C—Cl Cl CH₃ CH₃S—CH₂—mixture  98 racemic Cl C—Cl Cl CH₃ CH₃SO₂—CH₂— mixture  99 racemic ClC—Cl Cl CH₃ CF₃—CH₂— mixture 100 racemic Cl C—H Cl CH₃ methyl mixture101 racemic Cl C—H Cl CH₃ ethyl mixture 102 racemic Cl C—H Cl CH₃cyclopropyl mixture 103 racemic Cl C—H Cl CH₃ CH₃O—CH₂— mixture 104racemic Cl C—H Cl CH₃ cyclopropyl-CH₂— mixture 105 racemic Cl C—H Cl CH₃CH₃S—CH₂— mixture 106 racemic Cl C—H Cl CH₃ CH₃SO₂—CH₂— mixture 107racemic Cl C—H Cl CH₃ CF₃—CH₂— mixture 108 racemic Cl C—H Cl CH₃isopropyl mixture 109 racemic CF₃ C—H CF₃ CH₃ methyl mixture 110 racemicCF₃ C—H CF₃ CH₃ ethyl mixture 111 racemic CF₃ C—H CF₃ CH₃ cyclopropylmixture 112 racemic CF₃ C—H CF₃ CH₃ CH₃O—CH₂— mixture 113 racemic CF₃C—H CF₃ CH₃ cyclopropyl-CH₂— mixture 114 racemic CF₃ C—H CF₃ CH₃CH₃S—CH₂— mixture 115 racemic CF₃ C—H CF₃ CH₃ CH₃SO₂—CH₂— mixture 116racemic CF₃ C—H CF₃ CH₃ CF₃—CH₂— mixture 117 racemic CF₃ C—H CF₃ CH₃isopropyl mixture 118 racemic Cl C—H CF₃ CH₃ methyl mixture 119 racemicCl C—H CF₃ CH₃ ethyl mixture 120 racemic Cl C—H CF₃ CH₃ cyclopropylmixture 121 racemic Cl C—H CF₃ CH₃ CH₃O—CH₂— mixture 122 racemic Cl C—HCF₃ CH₃ cyclopropyl-CH₂— mixture 123 racemic Cl C—H CF₃ CH₃ CH₃S—CH₂—mixture 124 racemic Cl C—H CF₃ CH₃ CH₃SO₂—CH₂— mixture 125 racemic ClC—H CF₃ CH₃ CF₃—CH₂— mixture 126 racemic Cl C—H CF₃ CH₃ isopropylmixture 127 racemic Br C—H CF₃ CH₃ methyl mixture 128 racemic Br C—H CF₃CH₃ ethyl mixture 129 racemic Br C—H CF₃ CH₃ cyclopropyl mixture 130racemic Br C—H CF₃ CH₃ CH₃O—CH₂— mixture 131 racemic Br C—H CF₃ CH₃cyclopropyl-CH₂— mixture 132 racemic Br C—H CF₃ CH₃ CH₃S—CH₂— mixture133 racemic Br C—H CF₃ CH₃ CH₃SO₂—CH₂— mixture 134 racemic Br C—H CF₃CH₃ CF₃—CH₂— mixture 135 racemic Br C—H CF₃ CH₃ isopropyl mixture 136 asfor I** Cl C—Cl Cl CH₃ methyl 137 as for I** Cl C—Cl Cl CH₃ ethyl 138 asfor I** Cl C—Cl Cl CH₃ cyclopropyl 139 as for I** Cl C—Cl Cl CH₃CH₃O—CH₂— 140 as for I** Cl C—Cl Cl CH₃ cyclopropyl-CH₂— 141 as for I**Cl C—Cl Cl CH₃ isopropyl 142 as for I** Cl C—Cl Cl CH₃ CH₃S—CH₂— 143 asfor I** Cl C—Cl Cl CH₃ CH₃SO₂—CH₂— 144 as for I** Cl C—Cl Cl CH₃CF₃—CH₂— 145 as for I** Cl C—H Cl CH₃ methyl 146 as for I** Cl C—H ClCH₃ ethyl 147 as for I** Cl C—H Cl CH₃ cyclopropyl 148 as for I** Cl C—HCl CH₃ CH₃O—CH₂— 149 as for I** Cl C—H Cl CH₃ cyclopropyl-CH₂— 150 asfor I** Cl C—H Cl CH₃ CH₃S—CH₂— 151 as for I** Cl C—H Cl CH₃ CH₃SO₂—CH₂—152 as for I** Cl C—H Cl CH₃ CF₃—CH₂— 153 as for I** Cl C—H Cl CH₃isopropyl 154 as for I** CF₃ C—H CF₃ CH₃ methyl 155 as for I** CF₃ C—HCF₃ CH₃ ethyl 156 as for I** CF₃ C—H CF₃ CH₃ cyclopropyl 157 as for I**CF₃ C—H CF₃ CH₃ CH₃O—CH₂— 158 as for I** CF₃ C—H CF₃ CH₃cyclopropyl-CH₂— 159 as for I** CF₃ C—H CF₃ CH₃ CH₃S—CH₂— 160 as for I**CF₃ C—H CF₃ CH₃ CH₃SO₂—CH₂— 161 as for I** CF₃ C—H CF₃ CH₃ CF₃—CH₂— 162as for I** CF₃ C—H CF₃ CH₃ isopropyl 163 as for I** Cl C—H CF₃ CH₃methyl 164 as for I** Cl C—H CF₃ CH₃ ethyl 165 as for I** Cl C—H CF₃ CH₃cyclopropyl 166 as for I** Cl C—H CF₃ CH₃ CH₃O—CH₂— 167 as for I** ClC—H CF₃ CH₃ cyclopropyl-CH₂— 168 as for I** Cl C—H CF₃ CH₃ CH₃S—CH₂— 169as for I** Cl C—H CF₃ CH₃ CH₃SO₂—CH₂— 170 as for I** Cl C—H CF₃ CH₃CF₃—CH₂— 171 as for I** Cl C—H CF₃ CH₃ isopropyl 172 as for I** Br C—HCF₃ CH₃ methyl 173 as for I** Br C—H CF₃ CH₃ ethyl 174 as for I** Br C—HCF₃ CH₃ cyclopropyl 175 as for I** Br C—H CF₃ CH₃ CH₃O—CH₂— 176 as forI** Br C—H CF₃ CH₃ cyclopropyl-CH₂— 177 as for I** Br C—H CF₃ CH₃CH₃S—CH₂— 178 as for I** Br C—H CF₃ CH₃ CH₃SO₂—CH₂— 179 as for I** BrC—H CF₃ CH₃ CF₃—CH₂— 180 as for I** Br C—H CF₃ CH₃ isopropyl 181 racemicCl C—Cl Cl CF₃ methyl mixture 182 racemic Cl C—Cl Cl CF₃ ethyl mixture183 racemic Cl C—Cl Cl CF₃ cyclopropyl mixture 184 racemic Cl C—Cl ClCF₃ CH₃O—CH₂— mixture 185 racemic Cl C—Cl Cl CF₃ cyclopropyl-CH₂—mixture 186 racemic Cl C—Cl Cl CF₃ isopropyl mixture 187 racemic Cl C—ClCl CF₃ CH₃S—CH₂— mixture 188 racemic Cl C—Cl Cl CF₃ CH₃SO₂—CH₂— mixture189 racemic Cl C—Cl Cl CF₃ CF₃—CH₂— mixture 190 racemic Cl C—H Cl CF₃methyl mixture 191 racemic Cl C—H Cl CF₃ ethyl mixture 192 racemic ClC—H Cl CF₃ cyclopropyl mixture 193 racemic Cl C—H Cl CF₃ CH₃O—CH₂—mixture 194 racemic Cl C—H Cl CF₃ cyclopropyl-CH₂— mixture 195 racemicCl C—H Cl CF₃ CH₃S—CH₂— mixture 196 racemic Cl C—H Cl CF₃ CH₃SO₂—CH₂—mixture 197 racemic Cl C—H Cl CF₃ CF₃—CH₂— mixture 198 racemic Cl C—H ClCF₃ isopropyl mixture 199 racemic CF₃ C—H CF₃ CF₃ methyl mixture 200racemic CF₃ C—H CF₃ CF₃ ethyl mixture 201 racemic CF₃ C—H CF₃ CF₃cyclopropyl mixture 202 racemic CF₃ C—H CF₃ CF₃ CH₃O—CH₂— mixture 203racemic CF₃ C—H CF₃ CF₃ cyclopropyl-CH₂— mixture 204 racemic CF₃ C—H CF₃CF₃ CH₃S—CH₂— mixture 205 racemic CF₃ C—H CF₃ CF₃ CH₃SO₂—CH₂— mixture206 racemic CF₃ C—H CF₃ CF₃ CF₃—CH₂— mixture 207 racemic CF₃ C—H CF₃ CF₃isopropyl mixture 208 racemic Cl C—H CF₃ CF₃ methyl mixture 209 racemicCl C—H CF₃ CF₃ ethyl mixture 210 racemic Cl C—H CF₃ CF₃ cyclopropylmixture 211 racemic Cl C—H CF₃ CF₃ CH₃O—CH₂— mixture 212 racemic Cl C—HCF₃ CF₃ cyclopropyl-CH₂— mixture 213 racemic Cl C—H CF₃ CF₃ CH₃S—CH₂—mixture 214 racemic Cl C—H CF₃ CF₃ CH₃SO₂—CH₂— mixture 215 racemic ClC—H CF₃ CF₃ CF₃—CH₂— mixture 216 racemic Cl C—H CF₃ CF₃ isopropylmixture 217 racemic Br C—H CF₃ CF₃ methyl mixture 218 racemic Br C—H CF₃CF₃ ethyl mixture 219 racemic Br C—H CF₃ CF₃ cyclopropyl mixture 220racemic Br C—H CF₃ CF₃ CH₃O—CH₂— mixture 221 racemic Br C—H CF₃ CF₃cyclopropyl-CH₂— mixture 222 racemic Br C—H CF₃ CF₃ CH₃S—CH₂— mixture223 racemic Br C—H CF₃ CF₃ CH₃SO₂—CH₂— mixture 224 racemic Br C—H CF₃CF₃ CF₃—CH₂— mixture 225 racemic Br C—H CF₃ CF₃ isopropyl mixture 226 asfor I** Cl C—Cl Cl CF₃ methyl 227 as for I** Cl C—Cl Cl CF₃ ethyl 228 asfor I** Cl C—Cl Cl CF₃ cyclopropyl 229 as for I** Cl C—Cl Cl CF₃CH₃O—CH₂— 230 as for I** Cl C—Cl Cl CF₃ cyclopropyl-CH₂— 231 as for I**Cl C—Cl Cl CF₃ isopropyl 232 as for I** Cl C—Cl Cl CF₃ CH₃S—CH₂— 233 asfor I** Cl C—Cl Cl CF₃ CH₃SO₂—CH₂— 234 as for I** Cl C—Cl Cl CF₃CF₃—CH₂— 235 as for I** Cl C—H Cl CF₃ methyl 236 as for I** Cl C—H ClCF₃ ethyl 237 as for I** Cl C—H Cl CF₃ cyclopropyl 238 as for I** Cl C—HCl CF₃ CH₃O—CH₂— 239 as for I** Cl C—H Cl CF₃ cyclopropyl-CH₂— 240 asfor I** Cl C—H Cl CF₃ CH₃S—CH₂— 241 as for I** Cl C—H Cl CF₃ CH₃SO₂—CH₂—242 as for I** Cl C—H Cl CF₃ CF₃—CH₂— 243 as for I** Cl C—H Cl CF₃isopropyl 244 as for I** CF₃ C—H CF₃ CF₃ methyl 245 as for I** CF₃ C—HCF₃ CF₃ ethyl 246 as for I** CF₃ C—H CF₃ CF₃ cyclopropyl 247 as for I**CF₃ C—H CF₃ CF₃ CH₃O—CH₂— 248 as for I** CF₃ C—H CF₃ CF₃cyclopropyl-CH₂— 249 as for I** CF₃ C—H CF₃ CF₃ CH₃S—CH₂— 250 as for I**CF₃ C—H CF₃ CF₃ CH₃SO₂—CH₂— 251 as for I** CF₃ C—H CF₃ CF₃ CF₃—CH₂— 252as for I** CF₃ C—H CF₃ CF₃ isopropyl 253 as for I** Cl C—H CF₃ CF₃methyl 254 as for I** Cl C—H CF₃ CF₃ ethyl 255 as for I** Cl C—H CF₃ CF₃cyclopropyl 256 as for I** Cl C—H CF₃ CF₃ CH₃O—CH₂— 257 as for I** ClC—H CF₃ CF₃ cyclopropyl-CH₂— 258 as for I** Cl C—H CF₃ CF₃ CH₃S—CH₂— 259as for I** Cl C—H CF₃ CF₃ CH₃SO₂—CH₂— 260 as for I** Cl C—H CF₃ CF₃CF₃—CH₂— 261 as for I** Cl C—H CF₃ CF₃ isopropyl 262 as for I** Br C—HCF₃ CF₃ methyl 263 as for I** Br C—H CF₃ CF₃ ethyl 264 as for I** Br C—HCF₃ CF₃ cyclopropyl 265 as for I** Br C—H CF₃ CF₃ CH₃O—CH₂— 266 as forI** Br C—H CF₃ CF₃ cyclopropyl-CH₂— 267 as for I** Br C—H CF₃ CF₃CH₃S—CH₂— 268 as for I** Br C—H CF₃ CF₃ CH₃SO₂—CH₂— 269 as for I** BrC—H CF₃ CF₃ CF₃—CH₂— 270 as for I** Br C—H CF₃ CF₃ isopropyl 271 racemicCl C—Cl Cl Br methyl mixture 272 racemic Cl C—Cl Cl Br ethyl mixture 273racemic Cl C—Cl Cl Br cyclopropyl mixture 274 racemic Cl C—Cl Cl BrCH₃O—CH₂— mixture 275 racemic Cl C—Cl Cl Br cyclopropyl-CH₂— mixture 276racemic Cl C—Cl Cl Br isopropyl mixture 277 racemic Cl C—Cl Cl BrCH₃S—CH₂— mixture 278 racemic Cl C—Cl Cl Br CH₃SO₂—CH₂— mixture 279racemic Cl C—Cl Cl Br CF₃—CH₂— mixture 280 racemic Cl C—H Cl Br methylmixture 281 racemic Cl C—H Cl Br ethyl mixture 282 racemic Cl C—H Cl Brcyclopropyl mixture 283 racemic Cl C—H Cl Br CH₃O—CH₂— mixture 284racemic Cl C—H Cl Br cyclopropyl-CH₂— mixture 285 racemic Cl C—H Cl BrCH₃S—CH₂— mixture 286 racemic Cl C—H Cl Br CH₃SO₂—CH₂— mixture 287racemic Cl C—H Cl Br CF₃—CH₂— mixture 288 racemic Cl C—H Cl Br isopropylmixture 289 racemic CF₃ C—H CF₃ Br methyl mixture 290 racemic CF₃ C—HCF₃ Br ethyl mixture 291 racemic CF₃ C—H CF₃ Br cyclopropyl mixture 292racemic CF₃ C—H CF₃ Br CH₃O—CH₂— mixture 293 racemic CF₃ C—H CF₃ Brcyclopropyl-CH₂— mixture 294 racemic CF₃ C—H CF₃ Br CH₃S—CH₂— mixture295 racemic CF₃ C—H CF₃ Br CH₃SO₂—CH₂— mixture 296 racemic CF₃ C—H CF₃Br CF₃—CH₂— mixture 297 racemic CF₃ C—H CF₃ Br isopropyl mixture 298racemic Cl C—H CF₃ Br methyl mixture 299 racemic Cl C—H CF₃ Br ethylmixture 300 racemic Cl C—H CF₃ Br cyclopropyl mixture 301 racemic Cl C—HCF₃ Br CH₃O—CH₂— mixture 302 racemic Cl C—H CF₃ Br cyclopropyl-CH₂—mixture 303 racemic Cl C—H CF₃ Br CH₃S—CH₂— mixture 304 racemic Cl C—HCF₃ Br CH₃SO₂—CH₂— mixture 305 racemic Cl C—H CF₃ Br CF₃—CH₂— mixture306 racemic Cl C—H CF₃ Br isopropyl mixture 307 racemic Br C—H CF₃ Brmethyl mixture 308 racemic Br C—H CF₃ Br ethyl mixture 309 racemic BrC—H CF₃ Br cyclopropyl mixture 310 racemic Br C—H CF₃ Br CH₃O—CH₂—mixture 311 racemic Br C—H CF₃ Br cyclopropyl-CH₂— mixture 312 racemicBr C—H CF₃ Br CH₃S—CH₂— mixture 313 racemic Br C—H CF₃ Br CH₃SO₂—CH₂—mixture 314 racemic Br C—H CF₃ Br CF₃—CH₂— mixture 315 racemic Br C—HCF₃ Br isopropyl mixture 316 as for I** Cl C—Cl Cl Br methyl 317 as forI** Cl C—Cl Cl Br ethyl 318 as for I** Cl C—Cl Cl Br cyclopropyl 319 asfor I** Cl C—Cl Cl Br CH₃O—CH₂— 320 as for I** Cl C—Cl Cl Brcyclopropyl-CH₂— 321 as for I** Cl C—Cl Cl Br isopropyl 322 as for I**Cl C—Cl Cl Br CH₃S—CH₂— 323 as for I** Cl C—Cl Cl Br CH₃SO₂—CH₂— 324 asfor I** Cl C—Cl Cl Br CF₃—CH₂— 325 as for I** Cl C—H Cl Br methyl 326 asfor I** Cl C—H Cl Br ethyl 327 as for I** Cl C—H Cl Br cyclopropyl 328as for I** Cl C—H Cl Br CH₃O—CH₂— 329 as for I** Cl C—H Cl Brcyclopropyl-CH₂— 330 as for I** Cl C—H Cl Br CH₃S—CH₂— 331 as for I** ClC—H Cl Br CH₃SO₂—CH₂— 332 as for I** Cl C—H Cl Br CF₃—CH₂— 333 as forI** Cl C—H Cl Br isopropyl 334 as for I** CF₃ C—H CF₃ Br methyl 335 asfor I** CF₃ C—H CF₃ Br ethyl 336 as for I** CF₃ C—H CF₃ Br cyclopropyl337 as for I** CF₃ C—H CF₃ Br CH₃O—CH₂— 338 as for I** CF₃ C—H CF₃ Brcyclopropyl-CH₂— 339 as for I** CF₃ C—H CF₃ Br CH₃S—CH₂— 340 as for I**CF₃ C—H CF₃ Br CH₃SO₂—CH₂— 341 as for I** CF₃ C—H CF₃ Br CF₃—CH₂— 342 asfor I** CF₃ C—H CF₃ Br isopropyl 343 as for I** Cl C—H CF₃ Br methyl 344as for I** Cl C—H CF₃ Br ethyl 345 as for I** Cl C—H CF₃ Br cyclopropyl346 as for I** Cl C—H CF₃ Br CH₃O—CH₂— 347 as for I** Cl C—H CF₃ Brcyclopropyl-CH₂— 348 as for I** Cl C—H CF₃ Br CH₃S—CH₂— 349 as for I**Cl C—H CF₃ Br CH₃SO₂—CH₂— 350 as for I** Cl C—H CF₃ Br CF₃—CH₂— 351 asfor I** Cl C—H CF₃ Br isopropyl 352 as for I** Br C—H CF₃ Br methyl 353as for I** Br C—H CF₃ Br ethyl 354 as for I** Br C—H CF₃ Br cyclopropyl355 as for I** Br C—H CF₃ Br CH₃O—CH₂— 356 as for I** Br C—H CF₃ Brcyclopropyl-CH₂— 357 as for I** Br C—H CF₃ Br CH₃S—CH₂— 358 as for I**Br C—H CF₃ Br CH₃SO₂—CH₂— 359 as for I** Br C—H CF₃ Br CF₃—CH₂— 360 asfor I** Br C—H CF₃ Br isopropyl

TABLE E Compounds of formula Ie (Ie)

Comp Stereochemistry No. at * X1 X2 X3 R⁵ R⁸  1 racemic mixture Cl C—ClCl Cl methyl  2 racemic mixture Cl C—Cl Cl Cl ethyl  3 racemic mixtureCl C—Cl Cl Cl cyclopropyl  4 racemic mixture Cl C—Cl Cl Cl CH₃O—CH₂—  5racemic mixture Cl C—Cl Cl Cl cyclopropyl-CH₂—  6 racemic mixture ClC—Cl Cl Cl isopropyl  7 racemic mixture Cl C—Cl Cl Cl CH₃S—CH₂—  8racemic mixture Cl C—Cl Cl Cl CH₃SO₂—CH₂—  9 racemic mixture Cl C—Cl ClCl CF₃—CH₂—  10 racemic mixture Cl C—H Cl Cl methyl  11 racemic mixtureCl C—H Cl Cl ethyl  12 racemic mixture Cl C—H Cl Cl cyclopropyl  13racemic mixture Cl C—H Cl Cl CH₃O—CH₂—  14 racemic mixture Cl C—H Cl Clcyclopropyl-CH₂—  15 racemic mixture Cl C—H Cl Cl CH₃S—CH₂—  16 racemicmixture Cl C—H Cl Cl CH₃SO₂—CH₂—  17 racemic mixture Cl C—H Cl ClCF₃—CH₂—  18 racemic mixture Cl C—H Cl Cl isopropyl  19 racemic mixtureCF₃ C—H CF₃ Cl methyl  20 racemic mixture CF₃ C—H CF₃ Cl ethyl  21racemic mixture CF₃ C—H CF₃ Cl cyclopropyl  22 racemic mixture CF₃ C—HCF₃ Cl CH₃O—CH₂—  23 racemic mixture CF₃ C—H CF₃ Cl cyclopropyl-CH₂—  24racemic mixture CF₃ C—H CF₃ Cl CH₃S—CH₂—  25 racemic mixture CF₃ C—H CF₃Cl CH₃SO₂—CH₂—  26 racemic mixture CF₃ C—H CF₃ Cl CF₃—CH₂—  27 racemicmixture CF₃ C—H CF₃ Cl isopropyl  28 racemic mixture Cl C—H CF₃ Clmethyl  29 racemic mixture Cl C—H CF₃ Cl ethyl  30 racemic mixture ClC—H CF₃ Cl cyclopropyl  31 racemic mixture Cl C—H CF₃ Cl CH₃O—CH₂—  32racemic mixture Cl C—H CF₃ Cl cyclopropyl-CH₂—  33 racemic mixture ClC—H CF₃ Cl CH₃S—CH₂—  34 racemic mixture Cl C—H CF₃ Cl CH₃SO₂—CH₂—  35racemic mixture Cl C—H CF₃ Cl CF₃—CH₂—  36 racemic mixture Cl C—H CF₃ Clisopropyl  37 racemic mixture Br C—H CF₃ Cl methyl  38 racemic mixtureBr C—H CF₃ Cl ethyl  39 racemic mixture Br C—H CF₃ Cl cyclopropyl  40racemic mixture Br C—H CF₃ Cl CH₃O—CH₂—  41 racemic mixture Br C—H CF₃Cl cyclopropyl-CH₂—  42 racemic mixture Br C—H CF₃ Cl CH₃S—CH₂—  43racemic mixture Br C—H CF₃ Cl CH₃SO₂—CH₂—  44 racemic mixture Br C—H CF₃Cl CF₃—CH₂—  45 racemic mixture Br C—H CF₃ Cl isopropyl  46 as for I**Cl C—Cl Cl Cl methyl  47 as for I** Cl C—Cl Cl Cl ethyl  48 as for I**Cl C—Cl Cl Cl cyclopropyl  49 as for I** Cl C—Cl Cl Cl CH₃O—CH₂—  50 asfor I** Cl C—Cl Cl Cl cyclopropyl-CH₂—  51 as for I** Cl C—Cl Cl Clisopropyl  52 as for I** Cl C—Cl Cl Cl CH₃S—CH₂—  53 as for I** Cl C—ClCl Cl CH₃SO₂—CH₂—  54 as for I** Cl C—Cl Cl Cl CF₃—CH₂—  55 as for I**Cl C—H Cl Cl methyl  56 as for I** Cl C—H Cl Cl ethyl  57 as for I** ClC—H Cl Cl cyclopropyl  58 as for I** Cl C—H Cl Cl CH₃O—CH₂—  59 as forI** Cl C—H Cl Cl cyclopropyl-CH₂—  60 as for I** Cl C—H Cl Cl CH₃S—CH₂— 61 as for I** Cl C—H Cl Cl CH₃SO₂—CH₂—  62 as for I** Cl C—H Cl ClCF₃—CH₂—  63 as for I** Cl C—H Cl Cl isopropyl  64 as for I** CF₃ C—HCF₃ Cl methyl  65 as for I** CF₃ C—H CF₃ Cl ethyl  66 as for I** CF₃ C—HCF₃ Cl cyclopropyl  67 as for I** CF₃ C—H CF₃ Cl CH₃O—CH₂—  68 as forI** CF₃ C—H CF₃ Cl cyclopropyl-CH₂—  69 as for I** CF₃ C—H CF₃ ClCH₃S—CH₂—  70 as for I** CF₃ C—H CF₃ Cl CH₃SO₂—CH₂—  71 as for I** CF₃C—H CF₃ Cl CF₃—CH₂—  72 as for I** CF₃ C—H CF₃ Cl isopropyl  73 as forI** Cl C—H CF₃ Cl methyl  74 as for I** Cl C—H CF₃ Cl ethyl  75 as forI** Cl C—H CF₃ Cl cyclopropyl  76 as for I** Cl C—H CF₃ Cl CH₃O—CH₂—  77as for I** Cl C—H CF₃ Cl cyclopropyl-CH₂—  78 as for I** Cl C—H CF₃ ClCH₃S—CH₂—  79 as for I** Cl C—H CF₃ Cl CH₃SO₂—CH₂—  80 as for I** Cl C—HCF₃ Cl CF₃—CH₂—  81 as for I** Cl C—H CF₃ Cl isopropyl  82 as for I** BrC—H CF₃ Cl methyl  83 as for I** Br C—H CF₃ Cl ethyl  84 as for I** BrC—H CF₃ Cl cyclopropyl  85 as for I** Br C—H CF₃ Cl CH₃O—CH₂—  86 as forI** Br C—H CF₃ Cl cyclopropyl-CH₂—  87 as for I** Br C—H CF₃ ClCH₃S—CH₂—  88 as for I** Br C—H CF₃ Cl CH₃SO₂—CH₂—  89 as for I** Br C—HCF₃ Cl CF₃—CH₂—  90 as for I** Br C—H CF₃ Cl isopropyl  91 racemicmixture Cl C—Cl Cl CH₃ methyl  92 racemic mixture Cl C—Cl Cl CH₃ ethyl 93 racemic mixture Cl C—Cl Cl CH₃ cyclopropyl  94 racemic mixture ClC—Cl Cl CH₃ CH₃O—CH₂—  95 racemic mixture Cl C—Cl Cl CH₃cyclopropyl-CH₂—  96 racemic mixture Cl C—Cl Cl CH₃ isopropyl  97racemic mixture Cl C—Cl Cl CH₃ CH₃S—CH₂—  98 racemic mixture Cl C—Cl ClCH₃ CH₃SO₂—CH₂—  99 racemic mixture Cl C—Cl Cl CH₃ CF₃—CH₂— 100 racemicmixture Cl C—H Cl CH₃ methyl 101 racemic mixture Cl C—H Cl CH₃ ethyl 102racemic mixture Cl C—H Cl CH₃ cyclopropyl 103 racemic mixture Cl C—H ClCH₃ CH₃O—CH₂— 104 racemic mixture Cl C—H Cl CH₃ cyclopropyl-CH₂— 105racemic mixture Cl C—H Cl CH₃ CH₃S—CH₂— 106 racemic mixture Cl C—H ClCH₃ CH₃SO₂—CH₂— 107 racemic mixture Cl C—H Cl CH₃ CF₃—CH₂— 108 racemicmixture Cl C—H Cl CH₃ isopropyl 109 racemic mixture CF₃ C—H CF₃ CH₃methyl 110 racemic mixture CF₃ C—H CF₃ CH₃ ethyl 111 racemic mixture CF₃C—H CF₃ CH₃ cyclopropyl 112 racemic mixture CF₃ C—H CF₃ CH₃ CH₃O—CH₂—113 racemic mixture CF₃ C—H CF₃ CH₃ cyclopropyl-CH₂— 114 racemic mixtureCF₃ C—H CF₃ CH₃ CH₃S—CH₂— 115 racemic mixture CF₃ C—H CF₃ CH₃CH₃SO₂—CH₂— 116 racemic mixture CF₃ C—H CF₃ CH₃ CF₃—CH₂— 117 racemicmixture CF₃ C—H CF₃ CH₃ isopropyl 118 racemic mixture Cl C—H CF₃ CH₃methyl 119 racemic mixture Cl C—H CF₃ CH₃ ethyl 120 racemic mixture ClC—H CF₃ CH₃ cyclopropyl 121 racemic mixture Cl C—H CF₃ CH₃ CH₃O—CH₂— 122racemic mixture Cl C—H CF₃ CH₃ cyclopropyl-CH₂— 123 racemic mixture ClC—H CF₃ CH₃ CH₃S—CH₂— 124 racemic mixture Cl C—H CF₃ CH₃ CH₃SO₂—CH₂— 125racemic mixture Cl C—H CF₃ CH₃ CF₃—CH₂— 126 racemic mixture Cl C—H CF₃CH₃ isopropyl 127 racemic mixture Br C—H CF₃ CH₃ methyl 128 racemicmixture Br C—H CF₃ CH₃ ethyl 129 racemic mixture Br C—H CF₃ CH₃cyclopropyl 130 racemic mixture Br C—H CF₃ CH₃ CH₃O—CH₂— 131 racemicmixture Br C—H CF₃ CH₃ cyclopropyl-CH₂— 132 racemic mixture Br C—H CF₃CH₃ CH₃S—CH₂— 133 racemic mixture Br C—H CF₃ CH₃ CH₃SO₂—CH₂— 134 racemicmixture Br C—H CF₃ CH₃ CF₃—CH₂— 135 racemic mixture Br C—H CF₃ CH₃isopropyl 136 as for I** Cl C—Cl Cl CH₃ methyl 137 as for I** Cl C—Cl ClCH₃ ethyl 138 as for I** Cl C—Cl Cl CH₃ cyclopropyl 139 as for I** ClC—Cl Cl CH₃ CH₃O—CH₂— 140 as for I** Cl C—Cl Cl CH₃ cyclopropyl-CH₂— 141as for I** Cl C—Cl Cl CH₃ isopropyl 142 as for I** Cl C—Cl Cl CH₃CH₃S—CH₂— 143 as for I** Cl C—Cl Cl CH₃ CH₃SO₂—CH₂— 144 as for I** ClC—Cl Cl CH₃ CF₃—CH₂— 145 as for I** Cl C—H Cl CH₃ methyl 146 as for I**Cl C—H Cl CH₃ ethyl 147 as for I** Cl C—H Cl CH₃ cyclopropyl 148 as forI** Cl C—H Cl CH₃ CH₃O—CH₂— 149 as for I** Cl C—H Cl CH₃cyclopropyl-CH₂— 150 as for I** Cl C—H Cl CH₃ CH₃S—CH₂— 151 as for I**Cl C—H Cl CH₃ CH₃SO₂—CH₂— 152 as for I** Cl C—H Cl CH₃ CF₃—CH₂— 153 asfor I** Cl C—H Cl CH₃ isopropyl 154 as for I** CF₃ C—H CF₃ CH₃ methyl155 as for I** CF₃ C—H CF₃ CH₃ ethyl 156 as for I** CF₃ C—H CF₃ CH₃cyclopropyl 157 as for I** CF₃ C—H CF₃ CH₃ CH₃O—CH₂— 158 as for I** CF₃C—H CF₃ CH₃ cyclopropyl-CH₂— 159 as for I** CF₃ C—H CF₃ CH₃ CH₃S—CH₂—160 as for I** CF₃ C—H CF₃ CH₃ CH₃SO₂—CH₂— 161 as for I** CF₃ C—H CF₃CH₃ CF₃—CH₂— 162 as for I** CF₃ C—H CF₃ CH₃ isopropyl 163 as for I** ClC—H CF₃ CH₃ methyl 164 as for I** Cl C—H CF₃ CH₃ ethyl 165 as for I** ClC—H CF₃ CH₃ cyclopropyl 166 as for I** Cl C—H CF₃ CH₃ CH₃O—CH₂— 167 asfor I** Cl C—H CF₃ CH₃ cyclopropyl-CH₂— 168 as for I** Cl C—H CF₃ CH₃CH₃S—CH₂— 169 as for I** Cl C—H CF₃ CH₃ CH₃SO₂—CH₂— 170 as for I** ClC—H CF₃ CH₃ CF₃—CH₂— 171 as for I** Cl C—H CF₃ CH₃ isopropyl 172 as forI** Br C—H CF₃ CH₃ methyl 173 as for I** Br C—H CF₃ CH₃ ethyl 174 as forI** Br C—H CF₃ CH₃ cyclopropyl 175 as for I** Br C—H CF₃ CH₃ CH₃O—CH₂—176 as for I** Br C—H CF₃ CH₃ cyclopropyl-CH₂— 177 as for I** Br C—H CF₃CH₃ CH₃S—CH₂— 178 as for I** Br C—H CF₃ CH₃ CH₃SO₂—CH₂— 179 as for I**Br C—H CF₃ CH₃ CF₃—CH₂— 180 as for I** Br C—H CF₃ CH₃ isopropyl 181racemic mixture Cl C—Cl Cl CF₃ methyl 182 racemic mixture Cl C—Cl Cl CF₃ethyl 183 racemic mixture Cl C—Cl Cl CF₃ cyclopropyl 184 racemic mixtureCl C—Cl Cl CF₃ CH₃O—CH₂— 185 racemic mixture Cl C—Cl Cl CF₃cyclopropyl-CH₂— 186 racemic mixture Cl C—Cl Cl CF₃ isopropyl 187racemic mixture Cl C—Cl Cl CF₃ CH₃S—CH₂— 188 racemic mixture Cl C—Cl ClCF₃ CH₃SO₂—CH₂— 189 racemic mixture Cl C—Cl Cl CF₃ CF₃—CH₂— 190 racemicmixture Cl C—H Cl CF₃ methyl 191 racemic mixture Cl C—H Cl CF₃ ethyl 192racemic mixture Cl C—H Cl CF₃ cyclopropyl 193 racemic mixture Cl C—H ClCF₃ CH₃O—CH₂— 194 racemic mixture Cl C—H Cl CF₃ cyclopropyl-CH₂— 195racemic mixture Cl C—H Cl CF₃ CH₃S—CH₂— 196 racemic mixture Cl C—H ClCF₃ CH₃SO₂—CH₂— 197 racemic mixture Cl C—H Cl CF₃ CF₃—CH₂— 198 racemicmixture Cl C—H Cl CF₃ isopropyl 199 racemic mixture CF₃ C—H CF₃ CF₃methyl 200 racemic mixture CF₃ C—H CF₃ CF₃ ethyl 201 racemic mixture CF₃C—H CF₃ CF₃ cyclopropyl 202 racemic mixture CF₃ C—H CF₃ CF₃ CH₃O—CH₂—203 racemic mixture CF₃ C—H CF₃ CF₃ cyclopropyl-CH₂— 204 racemic mixtureCF₃ C—H CF₃ CF₃ CH₃S—CH₂— 205 racemic mixture CF₃ C—H CF₃ CF₃CH₃SO₂—CH₂— 206 racemic mixture CF₃ C—H CF₃ CF₃ CF₃—CH₂— 207 racemicmixture CF₃ C—H CF₃ CF₃ isopropyl 208 racemic mixture Cl C—H CF₃ CF₃methyl 209 racemic mixture Cl C—H CF₃ CF₃ ethyl 210 racemic mixture ClC—H CF₃ CF₃ cyclopropyl 211 racemic mixture Cl C—H CF₃ CF₃ CH₃O—CH₂— 212racemic mixture Cl C—H CF₃ CF₃ cyclopropyl-CH₂— 213 racemic mixture ClC—H CF₃ CF₃ CH₃S—CH₂— 214 racemic mixture Cl C—H CF₃ CF₃ CH₃SO₂—CH₂— 215racemic mixture Cl C—H CF₃ CF₃ CF₃—CH₂— 216 racemic mixture Cl C—H CF₃CF₃ isopropyl 217 racemic mixture Br C—H CF₃ CF₃ methyl 218 racemicmixture Br C—H CF₃ CF₃ ethyl 219 racemic mixture Br C—H CF₃ CF₃cyclopropyl 220 racemic mixture Br C—H CF₃ CF₃ CH₃O—CH₂— 221 racemicmixture Br C—H CF₃ CF₃ cyclopropyl-CH₂— 222 racemic mixture Br C—H CF₃CF₃ CH₃S—CH₂— 223 racemic mixture Br C—H CF₃ CF₃ CH₃SO₂—CH₂— 224 racemicmixture Br C—H CF₃ CF₃ CF₃—CH₂— 225 racemic mixture Br C—H CF₃ CF₃isopropyl 226 as for I** Cl C—Cl Cl CF₃ methyl 227 as for I** Cl C—Cl ClCF₃ ethyl 228 as for I** Cl C—Cl Cl CF₃ cyclopropyl 229 as for I** ClC—Cl Cl CF₃ CH₃O—CH₂— 230 as for I** Cl C—Cl Cl CF₃ cyclopropyl-CH₂— 231as for I** Cl C—Cl Cl CF₃ isopropyl 232 as for I** Cl C—Cl Cl CF₃CH₃S—CH₂— 233 as for I** Cl C—Cl Cl CF₃ CH₃SO₂—CH₂— 234 as for I** ClC—Cl Cl CF₃ CF₃—CH₂— 235 as for I** Cl C—H Cl CF₃ methyl 236 as for I**Cl C—H Cl CF₃ ethyl 237 as for I** Cl C—H Cl CF₃ cyclopropyl 238 as forI** Cl C—H Cl CF₃ CH₃O—CH₂— 239 as for I** Cl C—H Cl CF₃cyclopropyl-CH₂— 240 as for I** Cl C—H Cl CF₃ CH₃S—CH₂— 241 as for I**Cl C—H Cl CF₃ CH₃SO₂—CH₂— 242 as for I** Cl C—H Cl CF₃ CF₃—CH₂— 243 asfor I** Cl C—H Cl CF₃ isopropyl 244 as for I** CF₃ C—H CF₃ CF₃ methyl245 as for I** CF₃ C—H CF₃ CF₃ ethyl 246 as for I** CF₃ C—H CF₃ CF₃cyclopropyl 247 as for I** CF₃ C—H CF₃ CF₃ CH₃O—CH₂— 248 as for I** CF₃C—H CF₃ CF₃ cyclopropyl-CH₂— 249 as for I** CF₃ C—H CF₃ CF₃ CH₃S—CH₂—250 as for I** CF₃ C—H CF₃ CF₃ CH₃SO₂—CH₂— 251 as for I** CF₃ C—H CF₃CF₃ CF₃—CH₂— 252 as for I** CF₃ C—H CF₃ CF₃ isopropyl 253 as for I** ClC—H CF₃ CF₃ methyl 254 as for I** Cl C—H CF₃ CF₃ ethyl 255 as for I** ClC—H CF₃ CF₃ cyclopropyl 256 as for I** Cl C—H CF₃ CF₃ CH₃O—CH₂— 257 asfor I** Cl C—H CF₃ CF₃ cyclopropyl-CH₂— 258 as for I** Cl C—H CF₃ CF₃CH₃S—CH₂— 259 as for I** Cl C—H CF₃ CF₃ CH₃SO₂—CH₂— 260 as for I** ClC—H CF₃ CF₃ CF₃—CH₂— 261 as for I** Cl C—H CF₃ CF₃ isopropyl 262 as forI** Br C—H CF₃ CF₃ methyl 263 as for I** Br C—H CF₃ CF₃ ethyl 264 as forI** Br C—H CF₃ CF₃ cyclopropyl 265 as for I** Br C—H CF₃ CF₃ CH₃O—CH₂—266 as for I** Br C—H CF₃ CF₃ cyclopropyl-CH₂— 267 as for I** Br C—H CF₃CF₃ CH₃S—CH₂— 268 as for I** Br C—H CF₃ CF₃ CH₃SO₂—CH₂— 269 as for I**Br C—H CF₃ CF₃ CF₃—CH₂— 270 as for I** Br C—H CF₃ CF₃ isopropyl 271racemic mixture Cl C—Cl Cl Br methyl 272 racemic mixture Cl C—Cl Cl Brethyl 273 racemic mixture Cl C—Cl Cl Br cyclopropyl 274 racemic mixtureCl C—Cl Cl Br CH₃O—CH₂— 275 racemic mixture Cl C—Cl Cl Brcyclopropyl-CH₂— 276 racemic mixture Cl C—Cl Cl Br isopropyl 277 racemicmixture Cl C—Cl Cl Br CH₃S—CH₂— 278 racemic mixture Cl C—Cl Cl BrCH₃SO₂—CH₂— 279 racemic mixture Cl C—Cl Cl Br CF₃—CH₂— 280 racemicmixture Cl C—H Cl Br methyl 281 racemic mixture Cl C—H Cl Br ethyl 282racemic mixture Cl C—H Cl Br cyclopropyl 283 racemic mixture Cl C—H ClBr CH₃O—CH₂— 284 racemic mixture Cl C—H Cl Br cyclopropyl-CH₂— 285racemic mixture Cl C—H Cl Br CH₃S—CH₂— 286 racemic mixture Cl C—H Cl BrCH₃SO₂—CH₂— 287 racemic mixture Cl C—H Cl Br CF₃—CH₂— 288 racemicmixture Cl C—H Cl Br isopropyl 289 racemic mixture CF₃ C—H CF₃ Br methyl290 racemic mixture CF₃ C—H CF₃ Br ethyl 291 racemic mixture CF₃ C—H CF₃Br cyclopropyl 292 racemic mixture CF₃ C—H CF₃ Br CH₃O—CH₂— 293 racemicmixture CF₃ C—H CF₃ Br cyclopropyl-CH₂— 294 racemic mixture CF₃ C—H CF₃Br CH₃S—CH₂— 295 racemic mixture CF₃ C—H CF₃ Br CH₃SO₂—CH₂— 296 racemicmixture CF₃ C—H CF₃ Br CF₃—CH₂— 297 racemic mixture CF₃ C—H CF₃ Brisopropyl 298 racemic mixture Cl C—H CF₃ Br methyl 299 racemic mixtureCl C—H CF₃ Br ethyl 300 racemic mixture Cl C—H CF₃ Br cyclopropyl 301racemic mixture Cl C—H CF₃ Br CH₃O—CH₂— 302 racemic mixture Cl C—H CF₃Br cyclopropyl-CH₂— 303 racemic mixture Cl C—H CF₃ Br CH₃S—CH₂— 304racemic mixture Cl C—H CF₃ Br CH₃SO₂—CH₂— 305 racemic mixture Cl C—H CF₃Br CF₃—CH₂— 306 racemic mixture Cl C—H CF₃ Br isopropyl 307 racemicmixture Br C—H CF₃ Br methyl 308 racemic mixture Br C—H CF₃ Br ethyl 309racemic mixture Br C—H CF₃ Br cyclopropyl 310 racemic mixture Br C—H CF₃Br CH₃O—CH₂— 311 racemic mixture Br C—H CF₃ Br cyclopropyl-CH₂— 312racemic mixture Br C—H CF₃ Br CH₃S—CH₂— 313 racemic mixture Br C—H CF₃Br CH₃SO₂—CH₂— 314 racemic mixture Br C—H CF₃ Br CF₃—CH₂— 315 racemicmixture Br C—H CF₃ Br isopropyl 316 as for I** Cl C—Cl Cl Br methyl 317as for I** Cl C—Cl Cl Br ethyl 318 as for I** Cl C—Cl Cl Br cyclopropyl319 as for I** Cl C—Cl Cl Br CH₃O—CH₂— 320 as for I** Cl C—Cl Cl Brcyclopropyl-CH₂— 321 as for I** Cl C—Cl Cl Br isopropyl 322 as for I**Cl C—Cl Cl Br CH₃S—CH₂— 323 as for I** Cl C—Cl Cl Br CH₃SO₂—CH₂— 324 asfor I** Cl C—Cl Cl Br CF₃—CH₂— 325 as for I** Cl C—H Cl Br methyl 326 asfor I** Cl C—H Cl Br ethyl 327 as for I** Cl C—H Cl Br cyclopropyl 328as for I** Cl C—H Cl Br CH₃O—CH₂— 329 as for I** Cl C—H Cl Brcyclopropyl-CH₂— 330 as for I** Cl C—H Cl Br CH₃S—CH₂— 331 as for I** ClC—H Cl Br CH₃SO₂—CH₂— 332 as for I** Cl C—H Cl Br CF₃—CH₂— 333 as forI** Cl C—H Cl Br isopropyl 334 as for I** CF₃ C—H CF₃ Br methyl 335 asfor I** CF₃ C—H CF₃ Br ethyl 336 as for I** CF₃ C—H CF₃ Br cyclopropyl337 as for I** CF₃ C—H CF₃ Br CH₃O—CH₂— 338 as for I** CF₃ C—H CF₃ Brcyclopropyl-CH₂— 339 as for I** CF₃ C—H CF₃ Br CH₃S—CH₂— 340 as for I**CF₃ C—H CF₃ Br CH₃SO₂—CH₂— 341 as for I** CF₃ C—H CF₃ Br CF₃—CH₂— 342 asfor I** CF₃ C—H CF₃ Br isopropyl 343 as for I** Cl C—H CF₃ Br methyl 344as for I** Cl C—H CF₃ Br ethyl 345 as for I** Cl C—H CF₃ Br cyclopropyl346 as for I** Cl C—H CF₃ Br CH₃O—CH₂— 347 as for I** Cl C—H CF₃ Brcyclopropyl-CH₂— 348 as for I** Cl C—H CF₃ Br CH₃S—CH₂— 349 as for I**Cl C—H CF₃ Br CH₃SO₂—CH₂— 350 as for I** Cl C—H CF₃ Br CF₃—CH₂— 351 asfor I** Cl C—H CF₃ Br isopropyl 352 as for I** Br C—H CF₃ Br methyl 353as for I** Br C—H CF₃ Br ethyl 354 as for I** Br C—H CF₃ Br cyclopropyl355 as for I** Br C—H CF₃ Br CH₃O—CH₂— 356 as for I** Br C—H CF₃ Brcyclopropyl-CH₂— 357 as for I** Br C—H CF₃ Br CH₃S—CH₂— 358 as for I**Br C—H CF₃ Br CH₃SO₂—CH₂— 359 as for I** Br C—H CF₃ Br CF₃—CH₂— 360 asfor I** Br C—H CF₃ Br isopropyl

TABLE F Compounds of formula If (If)

Comp Stereochemistry No. at * X1 X2 X3 R⁵ R⁸  1 racemic mixture Cl C—ClCl Cl methyl  2 racemic mixture Cl C—Cl Cl Cl ethyl  3 racemic mixtureCl C—Cl Cl Cl cyclopropyl  4 racemic mixture Cl C—Cl Cl Cl CH₃O—CH₂—  5racemic mixture Cl C—Cl Cl Cl cyclopropyl-CH₂—  6 racemic mixture ClC—Cl Cl Cl isopropyl  7 racemic mixture Cl C—Cl Cl Cl CH₃S—CH₂—  8racemic mixture Cl C—Cl Cl Cl CH₃SO₂—CH₂—  9 racemic mixture Cl C—Cl ClCl CF₃—CH₂—  10 racemic mixture Cl C—H Cl Cl methyl  11 racemic mixtureCl C—H Cl Cl ethyl  12 racemic mixture Cl C—H Cl Cl cyclopropyl  13racemic mixture Cl C—H Cl Cl CH₃O—CH₂—  14 racemic mixture Cl C—H Cl Clcyclopropyl-CH₂—  15 racemic mixture Cl C—H Cl Cl CH₃S—CH₂—  16 racemicmixture Cl C—H Cl Cl CH₃SO₂—CH₂—  17 racemic mixture Cl C—H Cl ClCF₃—CH₂—  18 racemic mixture Cl C—H Cl Cl isopropyl  19 racemic mixtureCF₃ C—H CF₃ Cl methyl  20 racemic mixture CF₃ C—H CF₃ Cl ethyl  21racemic mixture CF₃ C—H CF₃ Cl cyclopropyl  22 racemic mixture CF₃ C—HCF₃ Cl CH₃O—CH₂—  23 racemic mixture CF₃ C—H CF₃ Cl cyclopropyl-CH₂—  24racemic mixture CF₃ C—H CF₃ Cl CH₃S—CH₂—  25 racemic mixture CF₃ C—H CF₃Cl CH₃SO₂—CH₂—  26 racemic mixture CF₃ C—H CF₃ Cl CF₃—CH₂—  27 racemicmixture CF₃ C—H CF₃ Cl isopropyl  28 racemic mixture Cl C—H CF₃ Clmethyl  29 racemic mixture Cl C—H CF₃ Cl ethyl  30 racemic mixture ClC—H CF₃ Cl cyclopropyl  31 racemic mixture Cl C—H CF₃ Cl CH₃O—CH₂—  32racemic mixture Cl C—H CF₃ Cl cyclopropyl-CH₂—  33 racemic mixture ClC—H CF₃ Cl CH₃S—CH₂—  34 racemic mixture Cl C—H CF₃ Cl CH₃SO₂—CH₂—  35racemic mixture Cl C—H CF₃ Cl CF₃—CH₂—  36 racemic mixture Cl C—H CF₃ Clisopropyl  37 racemic mixture Br C—H CF₃ Cl methyl  38 racemic mixtureBr C—H CF₃ Cl ethyl  39 racemic mixture Br C—H CF₃ Cl cyclopropyl  40racemic mixture Br C—H CF₃ Cl CH₃O—CH₂—  41 racemic mixture Br C—H CF₃Cl cyclopropyl-CH₂—  42 racemic mixture Br C—H CF₃ Cl CH₃S—CH₂—  43racemic mixture Br C—H CF₃ Cl CH₃SO₂—CH₂—  44 racemic mixture Br C—H CF₃Cl CF₃—CH₂—  45 racemic mixture Br C—H CF₃ Cl isopropyl  46 as for I**Cl C—Cl Cl Cl methyl  47 as for I** Cl C—Cl Cl Cl ethyl  48 as for I**Cl C—Cl Cl Cl cyclopropyl  49 as for I** Cl C—Cl Cl Cl CH₃O—CH₂—  50 asfor I** Cl C—Cl Cl Cl cyclopropyl-CH₂—  51 as for I** Cl C—Cl Cl Clisopropyl  52 as for I** Cl C—Cl Cl Cl CH₃S—CH₂—  53 as for I** Cl C—ClCl Cl CH₃SO₂—CH₂—  54 as for I** Cl C—Cl Cl Cl CF₃—CH₂—  55 as for I**Cl C—H Cl Cl methyl  56 as for I** Cl C—H Cl Cl ethyl  57 as for I** ClC—H Cl Cl cyclopropyl  58 as for I** Cl C—H Cl Cl CH₃O—CH₂—  59 as forI** Cl C—H Cl Cl cyclopropyl-CH₂—  60 as for I** Cl C—H Cl Cl CH₃S—CH₂— 61 as for I** Cl C—H Cl Cl CH₃SO₂—CH₂—  62 as for I** Cl C—H Cl ClCF₃—CH₂—  63 as for I** Cl C—H Cl Cl isopropyl  64 as for I** CF₃ C—HCF₃ Cl methyl  65 as for I** CF₃ C—H CF₃ Cl ethyl  66 as for I** CF₃ C—HCF₃ Cl cyclopropyl  67 as for I** CF₃ C—H CF₃ Cl CH₃O—CH₂—  68 as forI** CF₃ C—H CF₃ Cl cyclopropyl-CH₂—  69 as for I** CF₃ C—H CF₃ ClCH₃S—CH₂—  70 as for I** CF₃ C—H CF₃ Cl CH₃SO₂—CH₂—  71 as for I** CF₃C—H CF₃ Cl CF₃—CH₂—  72 as for I** CF₃ C—H CF₃ Cl isopropyl  73 as forI** Cl C—H CF₃ Cl methyl  74 as for I** Cl C—H CF₃ Cl ethyl  75 as forI** Cl C—H CF₃ Cl cyclopropyl  76 as for I** Cl C—H CF₃ Cl CH₃O—CH₂—  77as for I** Cl C—H CF₃ Cl cyclopropyl-CH₂—  78 as for I** Cl C—H CF₃ ClCH₃S—CH₂—  79 as for I** Cl C—H CF₃ Cl CH₃SO₂—CH₂—  80 as for I** Cl C—HCF₃ Cl CF₃—CH₂—  81 as for I** Cl C—H CF₃ Cl isopropyl  82 as for I** BrC—H CF₃ Cl methyl  83 as for I** Br C—H CF₃ Cl ethyl  84 as for I** BrC—H CF₃ Cl cyclopropyl  85 as for I** Br C—H CF₃ Cl CH₃O—CH₂—  86 as forI** Br C—H CF₃ Cl cyclopropyl-CH₂—  87 as for I** Br C—H CF₃ ClCH₃S—CH₂—  88 as for I** Br C—H CF₃ Cl CH₃SO₂—CH₂—  89 as for I** Br C—HCF₃ Cl CF₃—CH₂—  90 as for I** Br C—H CF₃ Cl isopropyl  91 racemicmixture Cl C—Cl Cl CH₃ methyl  92 racemic mixture Cl C—Cl Cl CH₃ ethyl 93 racemic mixture Cl C—Cl Cl CH₃ cyclopropyl  94 racemic mixture ClC—Cl Cl CH₃ CH₃O—CH₂—  95 racemic mixture Cl C—Cl Cl CH₃cyclopropyl-CH₂—  96 racemic mixture Cl C—Cl Cl CH₃ isopropyl  97racemic mixture Cl C—Cl Cl CH₃ CH₃S—CH₂—  98 racemic mixture Cl C—Cl ClCH₃ CH₃SO₂—CH₂—  99 racemic mixture Cl C—Cl Cl CH₃ CF₃—CH₂— 100 racemicmixture Cl C—H Cl CH₃ methyl 101 racemic mixture Cl C—H Cl CH₃ ethyl 102racemic mixture Cl C—H Cl CH₃ cyclopropyl 103 racemic mixture Cl C—H ClCH₃ CH₃O—CH₂— 104 racemic mixture Cl C—H Cl CH₃ cyclopropyl-CH₂— 105racemic mixture Cl C—H Cl CH₃ CH₃S—CH₂— 106 racemic mixture Cl C—H ClCH₃ CH₃SO₂—CH₂— 107 racemic mixture Cl C—H Cl CH₃ CF₃—CH₂— 108 racemicmixture Cl C—H Cl CH₃ isopropyl 109 racemic mixture CF₃ C—H CF₃ CH₃methyl 110 racemic mixture CF₃ C—H CF₃ CH₃ ethyl 111 racemic mixture CF₃C—H CF₃ CH₃ cyclopropyl 112 racemic mixture CF₃ C—H CF₃ CH₃ CH₃O—CH₂—113 racemic mixture CF₃ C—H CF₃ CH₃ cyclopropyl-CH₂— 114 racemic mixtureCF₃ C—H CF₃ CH₃ CH₃S—CH₂— 115 racemic mixture CF₃ C—H CF₃ CH₃CH₃SO₂—CH₂— 116 racemic mixture CF₃ C—H CF₃ CH₃ CF₃—CH₂— 117 racemicmixture CF₃ C—H CF₃ CH₃ isopropyl 118 racemic mixture Cl C—H CF₃ CH₃methyl 119 racemic mixture Cl C—H CF₃ CH₃ ethyl 120 racemic mixture ClC—H CF₃ CH₃ cyclopropyl 121 racemic mixture Cl C—H CF₃ CH₃ CH₃O—CH₂— 122racemic mixture Cl C—H CF₃ CH₃ cyclopropyl-CH₂— 123 racemic mixture ClC—H CF₃ CH₃ CH₃S—CH₂— 124 racemic mixture Cl C—H CF₃ CH₃ CH₃SO₂—CH₂— 125racemic mixture Cl C—H CF₃ CH₃ CF₃—CH₂— 126 racemic mixture Cl C—H CF₃CH₃ isopropyl 127 racemic mixture Br C—H CF₃ CH₃ methyl 128 racemicmixture Br C—H CF₃ CH₃ ethyl 129 racemic mixture Br C—H CF₃ CH₃cyclopropyl 130 racemic mixture Br C—H CF₃ CH₃ CH₃O—CH₂— 131 racemicmixture Br C—H CF₃ CH₃ cyclopropyl-CH₂— 132 racemic mixture Br C—H CF₃CH₃ CH₃S—CH₂— 133 racemic mixture Br C—H CF₃ CH₃ CH₃SO₂—CH₂— 134 racemicmixture Br C—H CF₃ CH₃ CF₃—CH₂— 135 racemic mixture Br C—H CF₃ CH₃isopropyl 136 as for I** Cl C—Cl Cl CH₃ methyl 137 as for I** Cl C—Cl ClCH₃ ethyl 138 as for I** Cl C—Cl Cl CH₃ cyclopropyl 139 as for I** ClC—Cl Cl CH₃ CH₃O—CH₂— 140 as for I** Cl C—Cl Cl CH₃ cyclopropyl-CH₂— 141as for I** Cl C—Cl Cl CH₃ isopropyl 142 as for I** Cl C—Cl Cl CH₃CH₃S—CH₂— 143 as for I** Cl C—Cl Cl CH₃ CH₃SO₂—CH₂— 144 as for I** ClC—Cl Cl CH₃ CF₃—CH₂— 145 as for I** Cl C—H Cl CH₃ methyl 146 as for I**Cl C—H Cl CH₃ ethyl 147 as for I** Cl C—H Cl CH₃ cyclopropyl 148 as forI** Cl C—H Cl CH₃ CH₃O—CH₂— 149 as for I** Cl C—H Cl CH₃cyclopropyl-CH₂— 150 as for I** Cl C—H Cl CH₃ CH₃S—CH₂— 151 as for I**Cl C—H Cl CH₃ CH₃SO₂—CH₂— 152 as for I** Cl C—H Cl CH₃ CF₃—CH₂— 153 asfor I** Cl C—H Cl CH₃ isopropyl 154 as for I** CF₃ C—H CF₃ CH₃ methyl155 as for I** CF₃ C—H CF₃ CH₃ ethyl 156 as for I** CF₃ C—H CF₃ CH₃cyclopropyl 157 as for I** CF₃ C—H CF₃ CH₃ CH₃O—CH₂— 158 as for I** CF₃C—H CF₃ CH₃ cyclopropyl-CH₂— 159 as for I** CF₃ C—H CF₃ CH₃ CH₃S—CH₂—160 as for I** CF₃ C—H CF₃ CH₃ CH₃SO₂—CH₂— 161 as for I** CF₃ C—H CF₃CH₃ CF₃—CH₂— 162 as for I** CF₃ C—H CF₃ CH₃ isopropyl 163 as for I** ClC—H CF₃ CH₃ methyl 164 as for I** Cl C—H CF₃ CH₃ ethyl 165 as for I** ClC—H CF₃ CH₃ cyclopropyl 166 as for I** Cl C—H CF₃ CH₃ CH₃O—CH₂— 167 asfor I** Cl C—H CF₃ CH₃ cyclopropyl-CH₂— 168 as for I** Cl C—H CF₃ CH₃CH₃S—CH₂— 169 as for I** Cl C—H CF₃ CH₃ CH₃SO₂—CH₂— 170 as for I** ClC—H CF₃ CH₃ CF₃—CH₂— 171 as for I** Cl C—H CF₃ CH₃ isopropyl 172 as forI** Br C—H CF₃ CH₃ methyl 173 as for I** Br C—H CF₃ CH₃ ethyl 174 as forI** Br C—H CF₃ CH₃ cyclopropyl 175 as for I** Br C—H CF₃ CH₃ CH₃O—CH₂—176 as for I** Br C—H CF₃ CH₃ cyclopropyl-CH₂— 177 as for I** Br C—H CF₃CH₃ CH₃S—CH₂— 178 as for I** Br C—H CF₃ CH₃ CH₃SO₂—CH₂— 179 as for I**Br C—H CF₃ CH₃ CF₃—CH₂— 180 as for I** Br C—H CF₃ CH₃ isopropyl 181racemic mixture Cl C—Cl Cl CF₃ methyl 182 racemic mixture Cl C—Cl Cl CF₃ethyl 183 racemic mixture Cl C—Cl Cl CF₃ cyclopropyl 184 racemic mixtureCl C—Cl Cl CF₃ CH₃O—CH₂— 185 racemic mixture Cl C—Cl Cl CF₃cyclopropyl-CH₂— 186 racemic mixture Cl C—Cl Cl CF₃ isopropyl 187racemic mixture Cl C—Cl Cl CF₃ CH₃S—CH₂— 188 racemic mixture Cl C—Cl ClCF₃ CH₃SO₂—CH₂— 189 racemic mixture Cl C—Cl Cl CF₃ CF₃—CH₂— 190 racemicmixture Cl C—H Cl CF₃ methyl 191 racemic mixture Cl C—H Cl CF₃ ethyl 192racemic mixture Cl C—H Cl CF₃ cyclopropyl 193 racemic mixture Cl C—H ClCF₃ CH₃O—CH₂— 194 racemic mixture Cl C—H Cl CF₃ cyclopropyl-CH₂— 195racemic mixture Cl C—H Cl CF₃ CH₃S—CH₂— 196 racemic mixture Cl C—H ClCF₃ CH₃SO₂—CH₂— 197 racemic mixture Cl C—H Cl CF₃ CF₃—CH₂— 198 racemicmixture Cl C—H Cl CF₃ isopropyl 199 racemic mixture CF₃ C—H CF₃ CF₃methyl 200 racemic mixture CF₃ C—H CF₃ CF₃ ethyl 201 racemic mixture CF₃C—H CF₃ CF₃ cyclopropyl 202 racemic mixture CF₃ C—H CF₃ CF₃ CH₃O—CH₂—203 racemic mixture CF₃ C—H CF₃ CF₃ cyclopropyl-CH₂— 204 racemic mixtureCF₃ C—H CF₃ CF₃ CH₃S—CH₂— 205 racemic mixture CF₃ C—H CF₃ CF₃CH₃SO₂—CH₂— 206 racemic mixture CF₃ C—H CF₃ CF₃ CF₃—CH₂— 207 racemicmixture CF₃ C—H CF₃ CF₃ isopropyl 208 racemic mixture Cl C—H CF₃ CF₃methyl 209 racemic mixture Cl C—H CF₃ CF₃ ethyl 210 racemic mixture ClC—H CF₃ CF₃ cyclopropyl 211 racemic mixture Cl C—H CF₃ CF₃ CH₃O—CH₂— 212racemic mixture Cl C—H CF₃ CF₃ cyclopropyl-CH₂— 213 racemic mixture ClC—H CF₃ CF₃ CH₃S—CH₂— 214 racemic mixture Cl C—H CF₃ CF₃ CH₃SO₂—CH₂— 215racemic mixture Cl C—H CF₃ CF₃ CF₃—CH₂— 216 racemic mixture Cl C—H CF₃CF₃ isopropyl 217 racemic mixture Br C—H CF₃ CF₃ methyl 218 racemicmixture Br C—H CF₃ CF₃ ethyl 219 racemic mixture Br C—H CF₃ CF₃cyclopropyl 220 racemic mixture Br C—H CF₃ CF₃ CH₃O—CH₂— 221 racemicmixture Br C—H CF₃ CF₃ cyclopropyl-CH₂— 222 racemic mixture Br C—H CF₃CF₃ CH₃S—CH₂— 223 racemic mixture Br C—H CF₃ CF₃ CH₃SO₂—CH₂— 224 racemicmixture Br C—H CF₃ CF₃ CF₃—CH₂— 225 racemic mixture Br C—H CF₃ CF₃isopropyl 226 as for I** Cl C—Cl Cl CF₃ methyl 227 as for I** Cl C—Cl ClCF₃ ethyl 228 as for I** Cl C—Cl Cl CF₃ cyclopropyl 229 as for I** ClC—Cl Cl CF₃ CH₃O—CH₂— 230 as for I** Cl C—Cl Cl CF₃ cyclopropyl-CH₂— 231as for I** Cl C—Cl Cl CF₃ isopropyl 232 as for I** Cl C—Cl Cl CF₃CH₃S—CH₂— 233 as for I** Cl C—Cl Cl CF₃ CH₃SO₂—CH₂— 234 as for I** ClC—Cl Cl CF₃ CF₃—CH₂— 235 as for I** Cl C—H Cl CF₃ methyl 236 as for I**Cl C—H Cl CF₃ ethyl 237 as for I** Cl C—H Cl CF₃ cyclopropyl 238 as forI** Cl C—H Cl CF₃ CH₃O—CH₂— 239 as for I** Cl C—H Cl CF₃cyclopropyl-CH₂— 240 as for I** Cl C—H Cl CF₃ CH₃S—CH₂— 241 as for I**Cl C—H Cl CF₃ CH₃SO₂—CH₂— 242 as for I** Cl C—H Cl CF₃ CF₃—CH₂— 243 asfor I** Cl C—H Cl CF₃ isopropyl 244 as for I** CF₃ C—H CF₃ CF₃ methyl245 as for I** CF₃ C—H CF₃ CF₃ ethyl 246 as for I** CF₃ C—H CF₃ CF₃cyclopropyl 247 as for I** CF₃ C—H CF₃ CF₃ CH₃O—CH₂— 248 as for I** CF₃C—H CF₃ CF₃ cyclopropyl-CH₂— 249 as for I** CF₃ C—H CF₃ CF₃ CH₃S—CH₂—250 as for I** CF₃ C—H CF₃ CF₃ CH₃SO₂—CH₂— 251 as for I** CF₃ C—H CF₃CF₃ CF₃—CH₂— 252 as for I** CF₃ C—H CF₃ CF₃ isopropyl 253 as for I** ClC—H CF₃ CF₃ methyl 254 as for I** Cl C—H CF₃ CF₃ ethyl 255 as for I** ClC—H CF₃ CF₃ cyclopropyl 256 as for I** Cl C—H CF₃ CF₃ CH₃O—CH₂— 257 asfor I** Cl C—H CF₃ CF₃ cyclopropyl-CH₂— 258 as for I** Cl C—H CF₃ CF₃CH₃S—CH₂— 259 as for I** Cl C—H CF₃ CF₃ CH₃SO₂—CH₂— 260 as for I** ClC—H CF₃ CF₃ CF₃—CH₂— 261 as for I** Cl C—H CF₃ CF₃ isopropyl 262 as forI** Br C—H CF₃ CF₃ methyl 263 as for I** Br C—H CF₃ CF₃ ethyl 264 as forI** Br C—H CF₃ CF₃ cyclopropyl 265 as for I** Br C—H CF₃ CF₃ CH₃O—CH₂—266 as for I** Br C—H CF₃ CF₃ cyclopropyl-CH₂— 267 as for I** Br C—H CF₃CF₃ CH₃S—CH₂— 268 as for I** Br C—H CF₃ CF₃ CH₃SO₂—CH₂— 269 as for I**Br C—H CF₃ CF₃ CF₃—CH₂— 270 as for I** Br C—H CF₃ CF₃ isopropyl 271racemic mixture Cl C—Cl Cl Br methyl 272 racemic mixture Cl C—Cl Cl Brethyl 273 racemic mixture Cl C—Cl Cl Br cyclopropyl 274 racemic mixtureCl C—Cl Cl Br CH₃O—CH₂— 275 racemic mixture Cl C—Cl Cl Brcyclopropyl-CH₂— 276 racemic mixture Cl C—Cl Cl Br isopropyl 277 racemicmixture Cl C—Cl Cl Br CH₃S—CH₂— 278 racemic mixture Cl C—Cl Cl BrCH₃SO₂—CH₂— 279 racemic mixture Cl C—Cl Cl Br CF₃—CH₂— 280 racemicmixture Cl C—H Cl Br methyl 281 racemic mixture Cl C—H Cl Br ethyl 282racemic mixture Cl C—H Cl Br cyclopropyl 283 racemic mixture Cl C—H ClBr CH₃O—CH₂— 284 racemic mixture Cl C—H Cl Br cyclopropyl-CH₂— 285racemic mixture Cl C—H Cl Br CH₃S—CH₂— 286 racemic mixture Cl C—H Cl BrCH₃SO₂—CH₂— 287 racemic mixture Cl C—H Cl Br CF₃—CH₂— 288 racemicmixture Cl C—H Cl Br isopropyl 289 racemic mixture CF₃ C—H CF₃ Br methyl290 racemic mixture CF₃ C—H CF₃ Br ethyl 291 racemic mixture CF₃ C—H CF₃Br cyclopropyl 292 racemic mixture CF₃ C—H CF₃ Br CH₃O—CH₂— 293 racemicmixture CF₃ C—H CF₃ Br cyclopropyl-CH₂— 294 racemic mixture CF₃ C—H CF₃Br CH₃S—CH₂— 295 racemic mixture CF₃ C—H CF₃ Br CH₃SO₂—CH₂— 296 racemicmixture CF₃ C—H CF₃ Br CF₃—CH₂— 297 racemic mixture CF₃ C—H CF₃ Brisopropyl 298 racemic mixture Cl C—H CF₃ Br methyl 299 racemic mixtureCl C—H CF₃ Br ethyl 300 racemic mixture Cl C—H CF₃ Br cyclopropyl 301racemic mixture Cl C—H CF₃ Br CH₃O—CH₂— 302 racemic mixture Cl C—H CF₃Br cyclopropyl-CH₂— 303 racemic mixture Cl C—H CF₃ Br CH₃S—CH₂— 304racemic mixture Cl C—H CF₃ Br CH₃SO₂—CH₂— 305 racemic mixture Cl C—H CF₃Br CF₃—CH₂— 306 racemic mixture Cl C—H CF₃ Br isopropyl 307 racemicmixture Br C—H CF₃ Br methyl 308 racemic mixture Br C—H CF₃ Br ethyl 309racemic mixture Br C—H CF₃ Br cyclopropyl 310 racemic mixture Br C—H CF₃Br CH₃O—CH₂— 311 racemic mixture Br C—H CF₃ Br cyclopropyl-CH₂— 312racemic mixture Br C—H CF₃ Br CH₃S—CH₂— 313 racemic mixture Br C—H CF₃Br CH₃SO₂—CH₂— 314 racemic mixture Br C—H CF₃ Br CF₃—CH₂— 315 racemicmixture Br C—H CF₃ Br isopropyl 316 as for I** Cl C—Cl Cl Br methyl 317as for I** Cl C—Cl Cl Br ethyl 318 as for I** Cl C—Cl Cl Br cyclopropyl319 as for I** Cl C—Cl Cl Br CH₃O—CH₂— 320 as for I** Cl C—Cl Cl Brcyclopropyl-CH₂— 321 as for I** Cl C—Cl Cl Br isopropyl 322 as for I**Cl C—Cl Cl Br CH₃S—CH₂— 323 as for I** Cl C—Cl Cl Br CH₃SO₂—CH₂— 324 asfor I** Cl C—Cl Cl Br CF₃—CH₂— 325 as for I** Cl C—H Cl Br methyl 326 asfor I** Cl C—H Cl Br ethyl 327 as for I** Cl C—H Cl Br cyclopropyl 328as for I** Cl C—H Cl Br CH₃O—CH₂— 329 as for I** Cl C—H Cl Brcyclopropyl-CH₂— 330 as for I** Cl C—H Cl Br CH₃S—CH₂— 331 as for I** ClC—H Cl Br CH₃SO₂—CH₂— 332 as for I** Cl C—H Cl Br CF₃—CH₂— 333 as forI** Cl C—H Cl Br isopropyl 334 as for I** CF₃ C—H CF₃ Br methyl 335 asfor I** CF₃ C—H CF₃ Br ethyl 336 as for I** CF₃ C—H CF₃ Br cyclopropyl337 as for I** CF₃ C—H CF₃ Br CH₃O—CH₂— 338 as for I** CF₃ C—H CF₃ Brcyclopropyl-CH₂— 339 as for I** CF₃ C—H CF₃ Br CH₃S—CH₂— 340 as for I**CF₃ C—H CF₃ Br CH₃SO₂—CH₂— 341 as for I** CF₃ C—H CF₃ Br CF₃—CH₂— 342 asfor I** CF₃ C—H CF₃ Br isopropyl 343 as for I** Cl C—H CF₃ Br methyl 344as for I** Cl C—H CF₃ Br ethyl 345 as for I** Cl C—H CF₃ Br cyclopropyl346 as for I** Cl C—H CF₃ Br CH₃O—CH₂— 347 as for I** Cl C—H CF₃ Brcyclopropyl-CH₂— 348 as for I** Cl C—H CF₃ Br CH₃S—CH₂— 349 as for I**Cl C—H CF₃ Br CH₃SO₂—CH₂— 350 as for I** Cl C—H CF₃ Br CF₃—CH₂— 351 asfor I** Cl C—H CF₃ Br isopropyl 352 as for I** Br C—H CF₃ Br methyl 353as for I** Br C—H CF₃ Br ethyl 354 as for I** Br C—H CF₃ Br cyclopropyl355 as for I** Br C—H CF₃ Br CH₃O—CH₂— 356 as for I** Br C—H CF₃ Brcyclopropyl-CH₂— 357 as for I** Br C—H CF₃ Br CH₃S—CH₂— 358 as for I**Br C—H CF₃ Br CH₃SO₂—CH₂— 359 as for I** Br C—H CF₃ Br CF₃—CH₂— 360 asfor I** Br C—H CF₃ Br isopropyl

Compounds from Tables A, B and C are preferred, with compounds fromTable B being particularly preferred.

In one embodiment of the invention component B is an insecticidalcompound selected from the group consisting of neonicotinoids, tetramicacids and tetronic acids, pyrethroids, diamides, carbamates, ethiprole,flupyradifurone, fipronil and-4-[[(6-Chloropyridin-3-yl)methyl](2,2-difluoroethyl)amino]furan-2(5H)-one.

In a further embodiment of the invention component B is an insecticidalcompound selected from the group consisting of neonicotinoids, tetramicacids, pyrethroids, diamides and-4-[[(6-Chloropyridin-3-yl)methyl](2,2-difluoroethyl)amino]furan-2(5H)-one.

In a further embodiment of the invention component B is an insecticidalcompound selected from the group consisting of neonicotinoids, tetramicacids, and pyrethroids.

In a further embodiment of the invention component B is an insecticidalcompound selected from the group consisting of imidacloprid thiacloprid,spirotetramat, spiromesifen, spirodiclofen, flubendiamide, ethiprole,flupyradifurone, thiodicarb, deltamethrin, beta-cyfluthrin, aldicarb,fipronil,4-[[(6-Chloropyridin-3-yl)methyl](2,2-difluoroethyl)amino]furan-2(5H)-one,lambda-cyhalothrin, and thiamethoxam.

In a further embodiment of the invention component B is an insecticidalcompound selected from the group consisting of imidacloprid,thiacloprid, spirotetramat, spirodiclofen, flubendiamide, deltamethrin,beta-cyfluthrin,4-[[(6-Chloropyridin-3-yl)methyl](2,2-difluoroethyl)amino]furan-2(5H)-one,lambda-cyhalothrin, and thiamethoxam

In one embodiment of the invention component B is an insecticidalcompound selected from the group consisting of

-   -   pymetrozine;    -   an organophosphate selected from the group consisting of        sulprofos, acephate, methyl parathion, azinphos-methyl,        demeton-s-methyl, heptenophos, thiometon, fenamiphos,        monocrotophos, profenofos, triazophos, methamidophos,        dimethoate, phosphamidon, malathion, chlorpyrifos, phosalone,        terbufos, fensulfothion, fonofos, phorate, phoxim,        pirimiphos-methyl, pirimiphos-ethyl, fenitrothion, fosthiazate        and diazinon;    -   a pyrethroid selected from the group consisting of permethrin,        cypermethrin, fenvalerate, esfenvalerate, deltamethrin,        cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin, bifenthrin,        fenpropathrin, cyfluthrin (including beta cyfluthrin),        tefluthrin, ethofenprox, natural pyrethrin, tetramethrin,        S-bioallethrin, fenfluthrin, prallethrin and        5-benzyl-3-furylmethyl-(E)-(1R,3S)-2,2-dimethyl-3-(2-oxothiolan-3-ylidenemethyl)cyclopropane        carboxylate;    -   a carbamate including those selected from the group consisting        of pirimicarb, triazamate, chloethocarb, carbofuran,        furathiocarb, ethiofencarb, aldicarb, thiofurox, carbosulfan,        bendiocarb, fenobucarb, propoxur, methomyl, thiodicarb and        oxamyl; a macrolide selected from the group consisting of        abamectin, emamectin benzoate, ivermectin, milbemycin, spinosad,        azadirachtin and spinetoram;    -   a diamide selected from the group consisting of flubendiamide,        chlorantraniliprole (Rynaxypyr®) and cyantraniliprole;    -   a neonicotinoid compound selected from the group consisting of        imidacloprid, thiacloprid, acetamiprid, nitenpyram, dinotefuran,        thiamethoxam, clothianidin, nithiazine and flonicamid; a        tetramic acid or tetronic acid selected from spirotetramat,        spirodiclofen and spiromesifen;    -   fipronil

In one embodiment of the invention component B is a compound selectedfrom the group consisting of abamectin, chlorpyrifos, cyantraniliprole,emamectin, lambda cyhalothrin, pymetrozine, spirotetramat, thiamethoxam,clothianidin, imidacloprid and chlorantraniliprole.

In one embodiment of the invention component B is a compound selectedfrom the group consisting of abamectin, chlorpyrifos, cyantraniliprole,emamectin, lambda cyhalothrin, pymetrozine, spirotetramat, andthiamethoxam.

In one embodiment of the invention component B is a compound selectedfrom the group consisting of abamectin, lambda cyhalothrin,spirotetramat and clothianidin. In one embodiment component B isabamectin. In one embodiment component B is lambda cyhalothrin. In oneembodiment component B is spirotetramat. In one embodiment component Bis clothianidin.

In a preferred embodiment of the invention component B is aninsecticidal compound selected from the group consisting of

-   -   a pyrethroid selected from the group consisting of permethrin,        cypermethrin, fenvalerate, esfenvalerate, deltamethrin,        cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin, bifenthrin,        fenpropathrin, cyfluthrin (including beta cyfluthrin),        tefluthrin, ethofenprox, natural pyrethrin, tetramethrin,        S-bioallethrin, fenfluthrin, prallethrin and        5-benzyl-3-furylmethyl-(E)-(1R,3S)-2,2-dimethyl-3-(2-oxothiolan-3-ylidenemethyl)cyclopropane        carboxylate;    -   a neonicotinoid compound selected from the group consisting of        imidacloprid, thiacloprid, acetamiprid, nitenpyram, dinotefuran,        thiamethoxam, clothianidin, nithiazine and flonicamid;    -   a tetramic acid or tetronic acid selected from the group        consisting of spirotetramat, spirodiclofen and spiromesifen.

In a preferred embodiment of the invention component B is a tetramicacid compound including those selected from spirotetramat andspirodiclofen, e.g. spirotetramat or spirodiclofen, more preferablyspirotetramat.

In a preferred embodiment of the invention component B is a pyrethroidselected from the group consisting of permethrin, cypermethrin,fenvalerate, esfenvalerate, deltamethrin, cyhalothrin,lambda-cyhalothrin, gamma-cyhalothrin, bifenthrin, fenpropathrin,cyfluthrin (including beta cyfluthrin), tefluthrin, ethofenprox, naturalpyrethrin, tetramethrin, S-bioallethrin, fenfluthrin, prallethrin and5-benzyl-3-furylmethyl-(E)-(1R,3S)-2,2-dimethyl-3-(2-oxothiolan-3-ylidenemethyl)cyclopropanecarboxylate, more preferably deltamethrin.

In a preferred embodiment of the invention component B is aneonicotinoid compound selected from the group consisting ofimidacloprid, thiacloprid, acetamiprid, nitenpyram, dinotefuran,thiamethoxam, clothianidin, nithiazine and flonicamid, more preferablyimidacloprid.

In a preferred embodiment of the invention component B is spirotetramat.

In a preferred embodiment of the invention component B is deltamethrin.

In a preferred embodiment of the invention component B is imidacloprid.

In a very preferred embodiment of the invention component A is apreferred group of compounds as described above and component B isspirotetramat.

In a very preferred embodiment of the invention component A is apreferred group of compounds as described above and component B isdeltamethrin.

In a very preferred embodiment of the invention component A is apreferred group of compounds as described above and component B isimidacloprid.

The invention also includes the following combinations:

A mixture of a compound selected from Tables A, B, C, D, E and F andabamectin.

A mixture of a compound selected from Tables A, B, C, D, E and F andchlorpyrifos.

A mixture of a compound selected from Tables A, B, C, D, E and F andcyantraniliprole.

A mixture of a compound selected from Tables A, B, C, D, E and F andemamectin.

A mixture of a compound selected from Tables A, B, C, D, E and F andcyhalothrin.

A mixture of a compound selected from Tables A, B, C, D, E and F andlambda cyhalothrin.

A mixture of a compound selected from Tables A, B, C, D, E and F andgamma cyhalothrin.

A mixture of a compound selected from Tables A, B, C, D, E and F andpymetrozine.

A mixture of a compound selected from Tables A, B, C, D, E and F andspirotetramat.

A mixture of a compound selected from Tables A, B, C, D, E and F andthiamethoxam.

A mixture of a compound selected from Tables A, B, C, D, E and F andchlorantraniliprole.

A mixture of a compound selected from Tables A, B, C, D, E and F andprofenofos.

A mixture of a compound selected from Tables A, B, C, D, E and F andacephate.

A mixture of a compound selected from Tables A, B, C, D, E and F andazinphos-methyl.

A mixture of a compound selected from Tables A, B, C, D, E and F andmethamidophos.

A mixture of a compound selected from Tables A, B, C, D, E and F andspinosad.

A mixture of a compound selected from Tables A, B, C, D, E and F andspinetoram.

A mixture of a compound selected from Tables A, B, C, D, E and F andflonicamid.

A mixture of a compound selected from Tables A, B, C, D, E and F andindoxacarb.

A mixture of a compound selected from Tables A, B, C, D, E and F andspirodiclofen.

A mixture of a compound selected from Tables A, B, C, D, E and F andspiromesifen.

A mixture of a compound selected from Tables A, B, C, D, E and F andsulfoxaflor.

A mixture of a compound selected from Tables A, B, C, D, E and F andfipronil.

A mixture of a compound selected from Tables A, B, C, D, E and F andimidacloprid.

A mixture of a compound selected from Tables A, B, C, D, E and F andthiacloprid.

A mixture of a compound selected from Tables A, B, C, D, E and F andacetamiprid.

A mixture of a compound selected from Tables A, B, C, D, E and F andnitenpyram.

A mixture of a compound selected from Tables A, B, C, D, E and F anddinotefuran.

A mixture of a compound selected from Tables A, B, C, D, E and F andclothianidin.

A mixture of a compound selected from Tables A, B, C, D, E and F andnithiazine.

A mixture of a compound selected from Tables A, B, C, D, E and F andpyriproxyfen.

A mixture of a compound selected from Tables A, B, C, D, E and F andbuprofezin.

A mixture of a compound selected from Tables A, B, C, D, E and F andpyrifluqinazon.

A mixture of a compound selected from Tables A, B, C, D, E and F andthiamethoxam and cyantraniliprole.

A mixture of a compound selected from Tables A, B, C, D, E and F andthiamethoxam and chlorantraniliprole.

A mixture of a compound selected from Tables A, B, C, D, E and F andsulfoxaflor.

A mixture of a compound selected from Tables A, B, C, D, E and F andLufeneron.

A mixture of a compound selected from Tables A, B, C, D, E and FDiafenthiuron.

A mixture of a compound selected from Tables A, B, C, D, E and F andFlubendiamide.

A mixture of a compound selected from Tables A, B, C, D, E and F andTefluthrin.

A mixture of a compound selected from Tables A, B, C, D, E and F andFipronil.

A mixture of a compound selected from Tables A, B, C, D, E and F andEthiprole.

A mixture of a compound selected from Tables A, B, C, D, E and F andFlupyradifurone.

A mixture of a compound selected from Tables A, B, C, D, E and F andIprodione.

A mixture of a compound selected from Tables A, B, C, D, E and F andThiodicarb.

A mixture of a compound selected from Tables A, B, C, D, E and F andDeltamethrin.

A mixture of a compound selected from Tables A, B, C, D, E and F andbeta-Cyfluthrin.

A mixture of a compound selected from Tables A, B, C, D, E and F andAldicarb

A mixture of a compound selected from Tables A, B, C, D, E and F and-4-[[(6-Chloropyridin-3-yl)methyl](2,2-difluoroethyl)amino]furan-2(5H)-one.

A mixture of a compound selected from Tables A, B, C, D, E and F andimidacloprid and Beta-cyfluthrin.

The present invention also relates to a method of controlling insects,acarines, nematodes or molluscs which comprises applying to a pest, to alocus of a pest, or to a plant susceptible to attack by a pest acombination of components A and B; seeds comprising a mixture ofcomponents A and B; and a method comprising coating a seed with amixture of components A and B.

The present invention also includes pesticidal mixtures comprising acomponent A and a component B in a synergistically effective amount;agricultural compositions comprising a mixture of component A and B in asynergistically effective amount; the use of a mixture of component Aand B in a synergistically effective amount for combating animal pests;a method of combating animal pests which comprises contacting the animalpests, their habit, breeding ground, food supply, plant, seed, soil,area, material or environment in which the animal pests are growing ormay grow, or the materials, plants, seeds, soils, surfaces or spaces tobe protected from animal attack or infestation with a mixture ofcomponent A and B in a synergistically effective amount; a method forprotecting crops from attack or infestation by animal pests whichcomprises contacting a crop with a mixture of component A and B in asynergistically effective amount; a method for the protection of seedsfrom soil insects and of the seedlings' roots and shoots from soil andfoliar insects comprising contacting the seeds before sowing and/orafter pre-germination with a mixture of component A and B in asynergistically effective amount; seeds comprising, e.g. coated with, amixture of component A and B in a synergistically effective amount; amethod comprising coating a seed with a mixture of component A and B ina synergistically effective amount; a method of controlling insects,acarines, nematodes or molluscs which comprises applying to a pest, to alocus of a pest, or to a plant susceptible to attack by a pest acombination of components A and B in a synergistically effective amount.Mixtures of A and B will normally be applied in an insecticidally,acaricidally, nematicidally or molluscicidally effective amount. Inapplication components A and B may be applied simultaneously orseparately.

The mixtures of the present invention can be used to controlinfestations of insect pests such as Lepidoptera, Diptera, Hemiptera,Thysanoptera, Orthoptera, Dictyoptera, Coleoptera, Siphonaptera,Hymenoptera and Isoptera and also other invertebrate pests, for example,acarine, nematode and mollusc pests. Insects, acarines, nematodes andmolluscs are herein collectively referred to as pests. The pests whichmay be controlled by the use of the invention compounds include thosepests associated with agriculture (which term includes the growing ofcrops for food and fiber products), horticulture and animal husbandry,companion animals, forestry and the storage of products of vegetableorigin (such as fruit, grain and timber); those pests associated withthe damage of man-made structures and the transmission of diseases ofman and animals; and also nuisance pests (such as flies). The mixturesof the invention are particularly effective against insects, acarinesand/or nematodes.

According to the invention “useful plants” typically comprise thefollowing species of plants: grape vines; cereals, such as wheat,barley, rye or oats; beet, such as sugar beet or fodder beet; fruits,such as pomes, stone fruits or soft fruits, for example apples, pears,plums, peaches, almonds, cherries, strawberries, raspberries orblackberries; leguminous plants, such as beans, lentils, peas orsoybeans; oil plants, such as rape, mustard, poppy, olives, sunflowers,coconut, castor oil plants, cocoa beans or groundnuts; cucumber plants,such as marrows, cucumbers or melons; fibre plants, such as cotton,flax, hemp or jute; citrus fruit, such as oranges, lemons, grapefruit ormandarins; vegetables, such as spinach, lettuce, asparagus, cabbages,carrots, onions, tomatoes, potatoes, cucurbits or paprika; lauraceae,such as avocados, cinnamon or camphor; maize; tobacco; nuts; coffee;sugar cane; tea; vines; hops; durian; bananas; natural rubber plants;turf or ornamentals, such as flowers, shrubs, broad-leaved trees orevergreens, for example conifers. This list does not represent anylimitation.

The term “useful plants” is to be understood as including also usefulplants that have been rendered tolerant to herbicides like bromoxynil orclasses of herbicides (such as, for example, HPPD inhibitors, ALSinhibitors, for example primisulfuron, prosulfuron and trifloxysulfuron,EPSPS (5-enol-pyrovyl-shikimate-3-phosphate-synthase) inhibitors, GS(glutamine synthetase) inhibitors) as a result of conventional methodsof breeding or genetic engineering. An example of a crop that has beenrendered tolerant to imidazolinones, e.g. imazamox, by conventionalmethods of breeding (mutagenesis) is Clearfield® summer rape (Canola).Examples of crops that have been rendered tolerant to herbicides orclasses of herbicides by genetic engineering methods include glyphosate-and glufosinate-resistant maize varieties commercially available underthe trade names RoundupReady®, Herculex I® and LibertyLink®.

Plants are also to be understood as being those which by the use ofrecombinant DNA techniques are capable of producing one or morepesticidal proteins which confer upon the transgenic plant tolerance orresistance to harmful pests, e.g. insect pests, nematode pests and thelike. Such pesticidal proteins include, without limitation, Cry proteinsfrom Bacillus thuringiensis Cry1Ab, Cry1Ac, Cry1F, Cry2Ab, Cry2Ae,Cry3A, Cry3Bb, or Cry9C; engineered proteins such as modified Cry3A(U.S. Pat. No. 7,030,295) or Cry1A.105; or vegetative insecticidalproteins such as Vip1, Vip2 or Vip3. A full list of Bt Cry proteins andVIPs useful in the invention can be found on the worldwide web atBacillus thuringiensis Toxin Nomenclature Database maintained by theUniversity of Sussex (see also, Crickmore et al. (1998) Microbiol. Mol.Biol. Rev. 62:807-813). Other pesticidal proteins useful in theinvention include proteins of bacteria colonizing nematodes, e.g.Photorhabdus spp. or Xenorhabdus spp.; toxins produced by animals, suchas scorpion toxins, arachnid toxins, wasp toxins, or otherinsect-specific neurotoxins; toxins produced by fungi, suchStreptomycetes toxins, plant lectins, such as pea or barley lectins;agglutinins; proteinase inhibitors, such as trypsin inhibitors, serineprotease inhibitors, patatin, cystatin or papain inhibitors;ribosome-inactivating proteins (RIP), such as ricin, maize-RIP, abrin,luffin, saporin or bryodin; steroid metabolism enzymes, such as3-hydroxysteroid oxidase, ecdysteroid-IDP-glycosyl-transferase,cholesterol oxidases, ecdysone inhibitors or HMG-CoA-reductase; ionchannel blockers, such as blockers of sodium or calcium channels;juvenile hormone esterase; diuretic hormone receptors (helicokininreceptors); stilben synthase, bibenzyl synthase, chitinases orglucanases. Further examples of such pesticidal proteins or transgenicplants capable of synthesizing such proteins are disclosed, e.g., inEP-A 374753, WO 93/007278, WO 95/34656, EP-A 427529, EP-A 451878, WO03/18810 and WO 03/52073. The methods for producing such transgenicplants are generally known to the person skilled in the art and some ofwhich are commercially available such as Agrisure®CB (corn producingCry1Ab), Agrisure®RW (corn producing mCry3A), Agrisure® Viptera (cornhybrids producing Vip3Aa); Agrisure300GT (corn hybrids producing Cry1Aband mCry3A); YieldGard® (corn hybrids producing the Cry1Ab protein),YieldGard® Plus (corn hybrids producing Cry1Ab and Cry3Bbl), Genuity®SmartStax® (corn hybrids with Cry1A.105, Cry2Ab2, Cry1F, Cry34/35,Cry3Bb); Herculex® I (corn hybrids producing Cry1Fa) and Herculex®RW(corn hybrids producing Cry34Ab1, Cry35Ab1 and the enzymePhosphinothricin-N-Acetyltransferase [PAT]); NuCOTN®33B (cottoncultivars producing Cry1Ac), Bollgard®I (cotton cultivars producingCry1Ac), Bollgard®II (cotton cultivars producing Cry1Ac and Cry2Ab2) andVIPCOT® (cotton cultivars producing a Vip3Aa).

The toxin contained in the transgenic plants imparts to the plantstolerance to harmful insects. Such insects can occur in any taxonomicgroup of insects, but are especially commonly found in the beetles(Coleoptera), two-winged insects (Diptera) and butterflies(Lepidoptera).

Further examples of such transgenic crops are:

1. Bt11 Maize from Syngenta Seeds SAS, Chemin de l'Hobit 27, F-31 790St. Sauveur, France, registration number C/FR/96/05/10. Geneticallymodified Zea mays which has been rendered resistant to attack by theEuropean corn borer (Ostrinia nubilalis and Sesamia nonagrioides) bytransgenic expression of a truncated CryIA(b) toxin. Bt11 maize alsotransgenically expresses the enzyme PAT to achieve tolerance to theherbicide glufosinate ammonium.

2. Bt176 Maize from Syngenta Seeds SAS, Chemin de l'Hobit 27, F-31 790St. Sauveur, France, registration number C/FR/96/05/10. Geneticallymodified Zea mays which has been rendered resistant to attack by theEuropean corn borer (Ostrinia nubilalis and Sesamia nonagrioides) bytransgenic expression of a CryIA(b) toxin. Bt176 maize alsotransgenically expresses the enzyme PAT to achieve tolerance to theherbicide glufosinate ammonium.

3. MIR604 Maize from Syngenta Seeds SAS, Chemin de l'Hobit 27, F-31 790St. Sauveur, France, registration number C/FR/96/05/10. Maize which hasbeen rendered insect-resistant by transgenic expression of a modifiedCryIIIA toxin. This toxin is Cry3A055 modified by insertion of acathepsin-D-protease recognition sequence. The preparation of suchtransgenic maize plants is described in WO 03/018810.

4. MON 863 Maize from Monsanto Europe S.A. 270-272 Avenue de Tervuren,B-1150 Brussels, Belgium, registration number C/DE/02/9. MON 863expresses a CryIIIB(b1) toxin and has resistance to certain Coleopterainsects.

5. IPC 531 Cotton from Monsanto Europe S.A. 270-272 Avenue de Tervuren,B-1150 Brussels, Belgium, registration number C/ES/96/02.

6. 1507 Maize from Pioneer Overseas Corporation, Avenue Tedesco, 7B-1160 Brussels, Belgium, registration number C/NL/00/10. Geneticallymodified maize for the expression of the protein Cry1F for achievingresistance to certain Lepidoptera insects and of the PAT protein forachieving tolerance to the herbicide glufosinate ammonium.

7. NK603×MON 810 Maize from Monsanto Europe S.A. 270-272 Avenue deTervuren, B-1150 Brussels, Belgium, registration number C/GB/02/M3/03.Consists of conventionally bred hybrid maize varieties by crossing thegenetically modified varieties NK603 and MON 810. NK603×MON 810 Maizetransgenically expresses the protein CP4 EPSPS, obtained fromAgrobacterium sp. strain CP4, which imparts tolerance to the herbicideRoundup® (contains glyphosate), and also a CryIA(b) toxin obtained fromBacillus thuringiensis subsp. kurstaki which brings about tolerance tocertain Lepidoptera, include the European corn borer.

Transgenic crops of insect-resistant plants are also described in BATS(Zentrum für Biosicherheit and Nachhaltigkeit, Zentrum BATS,Clarastrasse 13, 4058 Basel, Switzerland) Report 2003, (http://bats.ch).

Useful plants of elevated interest in connection with present inventionare cereals; soybean; rice; oil seed rape; pome fruits; stone fruits;peanuts; coffee; tea; strawberries; turf; vines and vegetables, such astomatoes, potatoes, cucurbits and lettuce.

The term “locus” of a useful plant as used herein is intended to embracethe place on which the useful plants are growing, where the plantpropagation materials of the useful plants are sown or where the plantpropagation materials of the useful plants will be placed into the soil.An example for such a locus is a field, on which crop plants aregrowing.

The term “plant propagation material” is understood to denote generativeparts of a plant, such as seeds, which can be used for themultiplication of the latter, and vegetative material, such as cuttingsor tubers, for example potatoes. There may be mentioned for exampleseeds (in the strict sense), roots, fruits, tubers, bulbs, rhizomes andparts of plants. Germinated plants and young plants which are to betransplanted after germination or after emergence from the soil, mayalso be mentioned. These young plants may be protected beforetransplantation by a total or partial treatment by immersion. Preferably“plant propagation material” is understood to denote seeds. Insecticidesthat are of particular interest for treating seeds include thiamethoxam,imidacloprid and clothianidin. Accordingly, in one embodiment componentB is selected from thiamethoxam, imidacloprid and clothianidin.

A further aspect of the instant invention is a method of protectingnatural substances of plant and/or animal origin, which have been takenfrom the natural life cycle, and/or their processed forms against attackof pests, which comprises applying to said natural substances of plantand/or animal origin or their processed forms a combination ofcomponents A and B in a synergistically effective amount.

According to the instant invention, the term “natural substances ofplant origin, which have been taken from the natural life cycle” denotesplants or parts thereof which have been harvested from the natural lifecycle and which are in the freshly harvested form. Examples of suchnatural substances of plant origin are stalks, leafs, tubers, seeds,fruits or grains. According to the instant invention, the term“processed form of a natural substance of plant origin” is understood todenote a form of a natural substance of plant origin that is the resultof a modification process. Such modification processes can be used totransform the natural substance of plant origin in a more storable formof such a substance (a storage good). Examples of such modificationprocesses are pre-drying, moistening, crushing, comminuting, grounding,compressing or roasting. Also falling under the definition of aprocessed form of a natural substance of plant origin is timber, whetherin the form of crude timber, such as construction timber, electricitypylons and barriers, or in the form of finished articles, such asfurniture or objects made from wood.

According to the instant invention, the term “natural substances ofanimal origin, which have been taken from the natural life cycle and/ortheir processed forms” is understood to denote material of animal originsuch as skin, hides, leather, furs, hairs and the like.

A preferred embodiment is a method of protecting natural substances ofplant origin, which have been taken from the natural life cycle, and/ortheir processed forms against attack of pests, which comprises applyingto said natural substances of plant and/or animal origin or theirprocessed forms a combination of components A and B in a synergisticallyeffective amount.

A further preferred embodiment is a method of protecting fruits,preferably pomes, stone fruits, soft fruits and citrus fruits, whichhave been taken from the natural life cycle, and/or their processedforms, which comprises applying to said fruits and/or their processedforms a combination of components A and B in a synergistically effectiveamount.

The combinations according to the present invention are furthermoreparticularly effective against the following pests: Myzus persicae(aphid), Aphis gossypii (aphid), Aphis fabae (aphid), Lygus spp.(capsids), Dysdercus spp. (capsids), Nilaparvata lugens (planthopper),Nephotettixc incticeps (leafhopper), Nezara spp. (stinkbugs), Euschistusspp. (stinkbugs), Leptocorisa spp. (stinkbugs), Frankliniellaoccidentalis (thrip), Thrips spp. (thrips), Leptinotarsa decemlineata(Colorado potato beetle), Anthonomus grandis (boll weevil), Aonidiellaspp. (scale insects), Trialeurodes spp. (white flies), Bemisia tabaci(white fly), Ostrinia nubilalis (European corn borer), Spodopteralittoralis (cotton leafworm), Heliothis virescens (tobacco budworm),Helicoverpa armigera (cotton bollworm), Helicoverpa zea (cottonbollworm), Sylepta derogata (cotton leaf roller), Pieris brassicae(white butterfly), Plutella xylostella (diamond back moth), Agrotis spp.(cutworms), Chilo suppressalis (rice stem borer), Locusta migratoria(locust), Chortiocetes terminifera (locust), Diabrotica spp.(rootworms), Panonychus ulmi (European red mite), Panonychus citri(citrus red mite), Tetranychus urticae (two-spotted spider mite),Tetranychus cinnabarinus (carmine spider mite), Phyllocoptruta oleivora(citrus rust mite), Polyphagotarsonemus latus (broad mite), Brevipalpusspp. (flat mites), Boophilus microplus (cattle tick), Dermacentorvariabilis (American dog tick), Ctenocephalides felis (cat flea),Liriomyza spp. (leafminer), Musca domestica (housefly), Aedes aegypti(mosquito), Anopheles spp. (mosquitoes), Culex spp. (mosquitoes),Lucillia spp. (blowflies), Blattella germanica (cockroach), Periplanetaamericana (cockroach), Blatta orientalis (cockroach), termites of theMastotermitidae (for example Mastotermes spp.), the Kalotermitidae (forexample Neotermes spp.), the Rhinotermitidae (for example Coptotermesformosanus, Reticulitermes flavipes, R. speratu, R. virginicus, R.hesperus, and R. santonensis) and the Termitidae (for exampleGlobitermes sulfureus), Solenopsis geminata (fire ant), Monomoriumpharaonis (pharaoh's ant), Damalinia spp. and Linognathus spp. (bitingand sucking lice), Meloidogyne spp. (root knot nematodes), Globoderaspp. and Heterodera spp. (cyst nematodes), Pratylenchus spp. (lesionnematodes), Rhodopholus spp. (banana burrowing nematodes), Tylenchulusspp. (citrus nematodes), Haemonchus contortus (barber pole worm),Caenorhabditis elegans (vinegar eelworm), Trichostrongylus spp. (gastrointestinal nematodes) and Deroceras reticulatum (slug).

The mixtures of the invention may be used for pest control on variousplants, including soybean, corn, sugarcane, alfalfa, brassicas, oilseedrape (e.g. canola), potatoes (including sweet potatoes), cotton, rice,coffee, citrus, almonds, fruiting vegetables (e.g. tomatoes, pepper,chili, eggplant, cucumber, squash etc.), tea, bulb vegetables (e.g.onion, leek etc.), grapes, pome fruit (e.g. apples, pears etc.), andstone fruit (e.g. pears, plums etc.).

The mixtures of the invention may be used on soybean to control, forexample, Elasmopalpus lignosellus, Diloboderus abderus, Diabroticaspeciosa, Sternechus subsignatus, Formicidae, Agrotis ypsilon, Julussspp., Anticarsia gemmatalis, Megascelis ssp., Procornitermes ssp.,Gryllotalpidae, Nezara viridula, Piezodorus spp., Acrosternum spp.,Neomegalotomus spp., Cerotoma trifurcata, Popillia japonica, Edessaspp., Liogenys fuscus, Euchistus heros, stalk borer, Scaptocoriscastanea, phyllophaga spp., Pseudoplusia includens, Spodoptera spp.,Bemisia tabaci, Agriotes spp. The mixtures of the invention arepreferably used on soybean to control Diloboderus abderus, Diabroticaspeciosa, Nezara viridula, Piezodorus spp., Acrosternum spp., Cerotomatrifurcata, Popillia japonica, Euchistus heros, phyllophaga spp.,Agriotes sp

The mixtures of the invention may be used on corn to control, forexample, Euchistus heros, Dichelops furcatus, Diloboderus abderus,Elasmopalpus lignosellus, Spodoptera frugiperda, Nezara viridula,Cerotoma trifurcata, Popillia japonica, Agrotis ypsilon, Diabroticaspeciosa, Heteroptera, Procornitermes ssp., Scaptocoris castanea,Formicidae, Julus ssp., Dalbulus maidis, Diabrotica virgifera, Mocislatipes, Bemisia tabaci, heliothis spp., Tetranychus spp., thrips spp.,phyllophaga spp., scaptocoris spp., Liogenys fuscus, Spodoptera spp.,Ostrinia spp., Sesamia spp., Agriotes spp. The mixtures of the inventionare preferably used on corn to control Euchistus heros, Dichelopsfurcatus, Diloboderus abderus, Nezara viridula, Cerotoma trifurcata,Popillia japonica, Diabrotica speciosa, Diabrotica virgifera,Tetranychus spp., thrips spp., phyllophaga spp., scaptocoris spp.,Agriotes spp.

The mixtures of the invention may be used on sugar cane to control, forexample, Sphenophorus spp., termites, Mahanarva spp. The mixtures of theinvention are preferably used on sugar cane to control termites,Mahanarva spp.

The mixtures of the invention may be used on alfalfa to control, forexample, Hypera brunneipennis, Hypera postica, Colias eurytheme, Collopsspp., Empoasca solana, Epitrix, Geocoris spp., Lygus hesperus, Lyguslineolaris, Spissistilus spp., Spodoptera spp., Trichoplusia ni. Themixtures of the invention are preferably used on alfalfa to controlHypera brunneipennis, Hypera postica, Empoasca solana, Epitrix, Lygushesperus, Lygus lineolaris, Trichoplusia ni.

The mixtures of the invention may be used on brassicas to control, forexample, Plutella xylostella, Pieris spp., Mamestra spp., Plusia spp.,Trichoplusia ni, Phyllotreta spp., Spodoptera spp., Empoasca solana,thrips spp., Spodoptera spp., Delia spp. The mixtures of the inventionare preferably used on brassicas to control Plutella xylostella Pierisspp., Plusia spp., Trichoplusia ni, Phyllotreta spp., thrips sp

The mixtures of the invention may be used on oil seed rape, e.g. canola,to control, for example, Meligethes spp., Ceutorhynchus napi, Psylloidesspp.

The mixtures of the invention may be used on potatoes, including sweetpotatoes, to control, for example, Empoasca spp., Leptinotarsa spp.,Diabrotica speciosa, Phthorimaea spp., Paratrioza spp., Maladeramatrida, Agriotes spp. The mixtures of the invention are preferably usedon potatoes, including sweet potatoes, to control Empoasca spp.,Leptinotarsa spp., Diabrotica speciosa, Phthorimaea spp., Paratriozaspp., Agriotes spp.

The mixtures of the invention may be used on cotton to control, forexample, Anthonomus grandis, Pectinophora spp., heliothis spp.,Spodoptera spp., Tetranychus spp., Empoasca spp., thrips spp., Bemisiatabaci, Lygus spp., phyllophaga spp., Scaptocoris spp. The mixtures ofthe invention are preferably used on cotton to control Anthonomusgrandis, Tetranychus spp., Empoasca spp., thrips spp., Lygus spp.,phyllophaga spp., Scaptocoris spp.

The mixtures of the invention may be used on rice to control, forexample, Leptocorisa spp., Cnaphalocrosis spp., Chilo spp., Scirpophagaspp., Lissorhoptrus spp., Oebalus pugnax. The mixtures of the inventionare preferably used on rice to control Leptocorisa spp., Lissorhoptrusspp., Oebalus pugnax.

The mixtures of the invention may be used on coffee to control, forexample, Hypothenemus Hampei, Perileucoptera Coffeella, Tetranychus spp.The mixtures of the invention are preferably used on coffee to controlHypothenemus Hampei, Perileucoptera Coffeella.

The mixtures of the invention may be used on citrus to control, forexample, Panonychus citri, Phyllocoptruta oleivora, Brevipalpus spp.,Diaphorina citri, Scirtothrips spp., thrips spp., Unaspis spp.,Ceratitis capitata, Phyllocnistis spp. The mixtures of the invention arepreferably used on citrus to control Panonychus citri, Phyllocoptrutaoleivora, Brevipalpus spp., Diaphorina citri, Scirtothrips spp., thripsspp., Phyllocnistis spp.

The mixtures of the invention may be used on almonds to control, forexample, Amyelois transitella, Tetranychus spp.

The mixtures of the invention may be used on fruiting vegetable,including tomatoes, pepper, chili, eggplant, cucumber, squash etc, tocontrol thrips spp., Tetranychus spp., Polyphagotarsonemus spp., Aculopsspp., Empoasca spp., Spodoptera spp., heliothis spp., Tuta absoluta,Liriomyza spp., Bemisia tabaci, Trialeurodes spp., Paratrioza spp.,Frankliniella occidentalis, Frankliniella spp., Anthonomus spp.,Phyllotreta spp., Amrasca spp., Epilachna spp., Halyomorpha spp.,Scirtothrips spp., Leucinodes spp., Neoleucinodes spp. The mixtures ofthe invention are preferably used on fruiting vegetable, includingtomatoes, pepper, chili, eggplant, cucumber, squash etc, to control, forexample, thrips spp., Tetranychus spp., Polyphagotarsonemus spp.,Aculops spp., Empoasca spp., Spodoptera spp., heliothis spp., Tutaabsoluta, Liriomyza spp., Paratrioza spp., Frankliniella occidentalis,Frankliniella spp., Amrasca spp., Scirtothrips spp., Leucinodes spp.,Neoleucinodes spp.

The mixtures of the invention may be used on tea to control, forexample, Pseudaulacaspis spp., Empoasca spp., Scirtothrips spp.,Caloptilia theivora. The mixtures of the invention are preferably usedon tea to control Empoasca spp., Scirtothrips spp.

The mixtures of the invention may be used on bulb vegetables, includingonion, leek etc to control, for example, thrips spp., Spodoptera spp.,heliothis spp. The mixtures of the invention are preferably used on bulbvegetables, including onion, leek etc to control thrips spp.

The mixtures of the invention may be used on grapes to control, forexample, Empoasca spp., Lobesia spp., Frankliniella spp., thrips spp.,Tetranychus spp., Rhipiphorothrips Cruentatus, EotetranychusWillamettei, Erythroneura Elegantula, Scaphoides spp. The mixtures ofthe invention are preferably used on grapes to control Frankliniellaspp., thrips spp., Tetranychus spp., Rhipiphorothrips Cruentatus,Scaphoides spp.

The mixtures of the invention may be used on pome fruit, includingapples, pairs etc, to control, for example, Cacopsylla spp., Psyllaspp., Panonychus ulmi, Cydia pomonella. The mixtures of the inventionare preferably used on pome fruit, including apples, pairs etc, tocontrol Cacopsylla spp., Psylla spp., Panonychus ulmi.

The mixtures of the invention may be used on stone fruit to control, forexample, Grapholita molesta, Scirtothrips spp., thrips spp.,Frankliniella spp., Tetranychus spp. The mixtures of the invention arepreferably used on stone fruit to control Scirtothrips spp., thripsspp., Frankliniella spp., Tetranychus spp.

The amount of a combination of the invention to be applied, will dependon various factors, such as the compounds employed; the subject of thetreatment, such as, for example plants, soil or seeds; the type oftreatment, such as, for example spraying, dusting or seed dressing; thepurpose of the treatment, such as, for example prophylactic ortherapeutic; the type of pest to be controlled or the application time.

The mixtures comprising a compound of formula I, e.g. those selectedfrom table A, and one or more active ingredients as described above canbe applied, for example, in a single “ready-mix” form, in a combinedspray mixture composed from separate formulations of the single activeingredient components, such as a “tank-mix”, and in a combined use ofthe single active ingredients when applied in a sequential manner, i.e.one after the other with a reasonably short period, such as a few hoursor days. The order of applying the compounds of formula I selected fromtable A and the active ingredients as described above is not essentialfor working the present invention.

The synergistic activity of the combination is apparent from the factthat the pesticidal activity of the composition of A+B is greater thanthe sum of the pesticidal activities of A and B.

The method of the invention comprises applying to the useful plants, thelocus thereof or propagation material thereof in admixture orseparately, a synergistically effective aggregate amount of a componentA and a component B.

Some of said combinations according to the invention have a systemicaction and can be used as foliar, soil and seed treatment pesticides.

With the combinations according to the invention it is possible toinhibit or destroy the pests which occur in plants or in parts of plants(fruit, blossoms, leaves, stems, tubers, roots) in different usefulplants, while at the same time the parts of plants which grow later arealso protected from attack by pests.

The combinations of the present invention are of particular interest forcontrolling pests in various useful plants or their seeds, especially infield crops such as potatoes, tobacco and sugarbeets, and wheat, rye,barley, oats, rice, maize, lawns, cotton, soybeans, oil seed rape, pulsecrops, sunflower, coffee, sugarcane, fruit and ornamentals inhorticulture and viticulture, in vegetables such as cucumbers, beans andcucurbits.

The combinations according to the invention are applied by treating thepests, the useful plants, the locus thereof, the propagation materialthereof, the natural substances of plant and/or animal origin, whichhave been taken from the natural life cycle, and/or their processedforms, or the industrial materials threatened by pests, attack with acombination of components A and B in a synergistically effective amount.

The combinations according to the invention may be applied before orafter infection or contamination of the useful plants, the propagationmaterial thereof, the natural substances of plant and/or animal origin,which have been taken from the natural life cycle, and/or theirprocessed forms, or the industrial materials by the pests.

The combinations according to the invention can be used for controlling,i.e. containing or destroying, pests of the abovementioned type whichoccur on useful plants in agriculture, in horticulture and in forests,or on organs of useful plants, such as fruits, flowers, foliage, stalks,tubers or roots, and in some cases even on organs of useful plants whichare formed at a later point in time remain protected against thesepests.

When applied to the useful plants the compound of formula I is generallyapplied at a rate of 1 to 500 g a.i./ha in association with 1 to 2000 ga.i./ha, of a compound of component B, depending on the class ofchemical employed as component B.

Generally for plant propagation material, such as seed treatment,application rates can vary from 0.001 to 10 g/kg of seeds of activeingredients. When the combinations of the present invention are used fortreating seed, rates of 0.001 to 5 g of a compound of formula I per kgof seed, preferably from 0.01 to 1 g per kg of seed, and 0.001 to 5 g ofa compound of component B, per kg of seed, preferably from 0.01 to 1 gper kg of seed, are generally sufficient.

The weight ratio of A to B may generally be between 1000:1 and 1:1000.In other embodiments that weight ratio of A to B may be between 500:1 to1:500, for example between 100:1 to 1:100, for example between 1:50 to50:1, for example 1:20 to 20:1, for example between 1:10 to 10:1 forexample between 1:5 to 5:1.

When component B is a tetramic acid such as spirotetramat the weightratio of A to B may be for example 1.5:1 to 1:2000, e.g. 1.5:1 to1:1000, e.g. 1:10 to 1:1000, e.g. 1:50 to 1:1000. Preferably component Ais a compound selected form the preferred groups of compounds above,more preferably compound B15. For example when component A is a compoundof formula B15 and component B is spirotetramat the weight ratio of A:Bmay be 1:10 to 1:1000.

When component B is a pyrethroid such as deltamethrin the weight ratioof A to B may be for example 1:10 to 100:1, e.g. 1:5 to 50:1, e.g. 1:1.5to 20:1 Preferably component A is a compound selected form the preferredgroups of compounds above, more preferably compound B15. For examplewhen component A is a compound of formula B15 and component B isdeltamethrin the weight ratio of A:B may be 1:5 to 50:1.

When component B is a neonicotinoid such as imidacloprid the weightratio of A to B may be for example 1.5:1 to 1:500, e.g. 1.5:1 to 1:300,e.g. 1:10 to 1:270. Preferably component A is a compound selected formthe preferred groups of compounds above, more preferably compound B15.For example when component A is a compound of formula B15 and componentB is imidacloprid the weight ratio of A:B may be 1.5:1 to 1:300.

The invention also provides pesticidal mixtures comprising a combinationof components A and B as mentioned above in a synergistically effectiveamount, together with an agriculturally acceptable carrier, andoptionally a surfactant.

The compositions of the invention may be employed in any conventionalform, for example in the form of a twin pack, a powder for dry seedtreatment (DS), an emulsion for seed treatment (ES), a flowableconcentrate for seed treatment (FS), a solution for seed treatment (LS),a water dispersible powder for seed treatment (WS), a capsule suspensionfor seed treatment (CF), a gel for seed treatment (GF), an emulsionconcentrate (EC), a suspension concentrate (SC), a suspo-emulsion (SE),a capsule suspension (CS), a water dispersible granule (WG), anemulsifiable granule (EG), an emulsion, water in oil (EO), an emulsion,oil in water (EW), a micro-emulsion (ME), an oil dispersion (OD), an oilmiscible flowable (OF), an oil miscible liquid (OL), a solubleconcentrate (SL), an ultra-low volume suspension (SU), an ultra-lowvolume liquid (UL), a technical concentrate (TK), a dispersibleconcentrate (DC), a wettable powder (WP), a soluble granule (SG) or anytechnically feasible formulation in combination with agriculturallyacceptable adjuvants.

Such compositions may be produced in conventional manner, e.g. by mixingthe active ingredients with appropriate formulation inerts (diluents,solvents, fillers and optionally other formulating ingredients such assurfactants, biocides, anti-freeze, stickers, thickeners and compoundsthat provide adjuvancy effects). Also conventional slow releaseformulations may be employed where long lasting efficacy is intended.Particularly formulations to be applied in spraying forms, such as waterdispersible concentrates (e.g. EC, SC, DC, OD, SE, EW, EO and the like),wettable powders and granules, may contain surfactants such as wettingand dispersing agents and other compounds that provide adjuvancyeffects, e.g. the condensation product of formaldehyde with naphthalenesulphonate, an alkylarylsulphonate, a lignin sulphonate, a fatty alkylsulphate, and ethoxylated alkylphenol and an ethoxylated fatty alcohol.

A seed dressing formulation is applied in a manner known per se to theseeds employing the combination of the invention and a diluent insuitable seed dressing formulation form, e.g. as an aqueous suspensionor in a dry powder form having good adherence to the seeds. Such seeddressing formulations are known in the art. Seed dressing formulationsmay contain the single active ingredients or the combination of activeingredients in encapsulated form, e.g. as slow release capsules ormicrocapsules. A typical a tank-mix formulation for seed treatmentapplication comprises 0.25 to 80%, especially 1 to 75%, of the desiredingredients, and 99.75 to 20%, especially 99 to 25%, of a solid orliquid auxiliaries (including, for example, a solvent such as water),where the auxiliaries can be a surfactant in an amount of 0 to 40%,especially 0.5 to 30%, based on the tank-mix formulation. A typicalpre-mix formulation for seed treatment application comprises 0.5 to99.9%, especially 1 to 95%, of the desired ingredients, and 99.5 to0.1%, especially 99 to 5%, of a solid or liquid adjuvant (including, forexample, a solvent such as water), where the auxiliaries can be asurfactant in an amount of 0 to 50%, especially 0.5 to 40%, based on thepre-mix formulation.

In general, the formulations include from 0.01 to 90% by weight ofactive agent, from 0 to 20% agriculturally acceptable surfactant and 10to 99.99% solid or liquid formulation inerts and adjuvant(s), the activeagent consisting of at least the compound of formula I together with acompound of component B, and optionally other active agents,particularly microbiocides or conservatives or the like. Concentratedforms of compositions generally contain in between about 2 and 80%,preferably between about 5 and 70% by weight of active agent.Application forms of formulation may for example contain from 0.01 to20% by weight, preferably from 0.01 to 5% by weight of active agent.Whereas commercial products will preferably be formulated asconcentrates, the end user will normally employ diluted formulations.

EXAMPLES

A synergistic effect exists whenever the action of an active ingredientcombination is greater than the sum of the actions of the individualcomponents.

The action to be expected E for a given active ingredient combinationobeys the so-called COLBY formula and can be calculated as follows(COLBY, S. R. “Calculating synergistic and antagonistic responses ofherbicide combination”. Weeds, Vol. 15, pages 20-22; 1967):

ppm=milligrams of active ingredient (=a.i.) per liter of spray mixtureX=% action by active ingredient A) using p ppm of active ingredientY=% action by active ingredient B) using q ppm of active ingredient.

According to COLBY, the expected (additive) action of active ingredientsA)+B) using p+q ppm of active ingredient is

$E = {X + Y - \frac{X \cdot Y}{100}}$

If the action actually observed (O) is greater than the expected action(E), then the action of the combination is super-additive, i.e. there isa synergistic effect. In mathematical terms the synergism factor SFcorresponds to O/E. In the agricultural practice an SF of ≧1.2 indicatessignificant improvement over the purely complementary addition ofactivities (expected activity), while an SF of ≦0.9 in the practicalapplication routine signals a loss of activity compared to the expectedactivity.

Tables 1, 2 and 3 show mixtures of the present invention demonstratingnotable synergistic effects. As the percent of mortality cannot exceed100 percent, the unexpected increase in insecticidal activity can begreatest only when the separate active ingredient components alone areat application rates providing considerably less than 100 percentcontrol. Synergy may not be evident at low application rates where theindividual active ingredient components alone have little activity.However, in some instances high activity was observed for combinationswherein individual active ingredient alone at the same application ratehad essentially no activity. The synergism is remarkable.

Heliothis virescens (Tobacco Budworm)

Eggs (0-24 h old) are placed in 24-well microtiter plate on artificialdiet and treated with test solutions (DMSO) by pipetting. After anincubation period of 4 days, samples are checked for larval mortality.

TABLE 1 B15 + DMET B15 DMET Application oberved observed observedexpected ppm control % control % control % control % difference B15 +DMET 1.6 + 0.1 100 95 0 95 +5 B15 + DMET 0.8 + 0.05 95 85 0 85 +10 B15 +DMET 0.4 + 0.025 85 75 0 75 +10 B15 + DMET 0.2 + 0.0125 80 75 0 75 +5B15 + DMET 0.1 + 0.0062 75 55 0 55 +20 B15 + DMET 1.6 + 0.2 90 95 0 95−5 B15 + DMET 0.8 + 0.1 90 85 0 85 +5 B15 + DMET 0.4 + 0.05 85 75 0 75+10 B15 + DMET 0.2 + 0.025 85 75 0 75 +10 B15 + DMET 0.1 + 0.0125 80 550 55 +25 B15 + DMET 0.8 + 0.2 95 85 0 85 +10 B15 + DMET 0.4 + 0.1 90 750 75 +15 B15 + DMET 0.2 + 0.05 85 75 0 75 +10 B15 + DMET 0.1 + 0.025 5555 0 55 0 B15 + DMET 0.8 + 0.4 90 85 0 85 +5 B15 + DMET 0.4 + 0.2 85 750 75 +10 B15 + DMET 0.2 + 0.1 90 75 0 75 +15 B15 + DMET 0.1 + 0.05 65 550 55 +10 B15 + DMET 0.8 + 0.8 95 85 0 85 +10 B15 + DMET 0.4 + 0.4 75 750 75 0 B15 + DMET 0.2 + 0.2 70 75 0 75 −5 B15 + DMET 0.1 + 0.1 60 55 055 +5

TABLE 2 B15 + SPAT B15 SPAT Application oberved observed observedexpected ppm control % control % control % control % difference B15 +SPAT  0.8 + 50 95 90 0 90 +5 B15 + SPAT  0.4 + 25 90 90 0 90 0 B15 +SPAT  0.2 + 12.5 80 85 0 85 −5 B15 + SPAT  0.1 + 6.25 75 0 0 0 +75 B15 +SPAT  0.4 + 50 90 90 0 90 0 B15 + SPAT  0.2 + 25 90 85 0 85 +5 B15 +SPAT  0.1 + 12.5 55 0 0 0 +55 B15 + SPAT  0.2 + 50 85 85 0 85 0 B15 +SPAT  0.1 + 25 70 0 0 0 +70 B15 + SPAT  0.2 + 100 90 85 0 85 +5 B15 +SPAT  0.1 + 50 75 0 0 0 +75 B15 + SPAT 0.05 + 25 55 0 0 0 +55 B15 + SPAT 0.2 + 200 90 85 55 93.25 −3.25 B15 + SPAT  0.1 + 100 85 0 0 0 +85 B15 +SPAT 0.05 + 50 40 0 0 0 +40Tetranychus urticae (Two-Spotted Spider Mite)

Bean leaf discs on agar in 24-well microtiter plates are sprayed withtest solutions (DMSO). After drying, the leaf discs are infested withmite populations of mixed ages. 8 days later, discs are checked formobile stages (I removed “mixed population”) mortality.

TABLE 3 B15 + IMID B15 IMID Application oberved observed observedexpected ppm control % control % control % control % difference B15 +IMID  1.5 + 25 85 30 0 30 +55 B15 + IMID  1.5 + 50 95 30 0 30 +65 B15 +IMID  0.75 + 25 35 0 0 0 +35 B15 + IMID 0.375 + 12.5 30 0 0 0 +30 B15 +IMID  1.5 + 100 90 30 0 30 +60 B15 + IMID  0.75 + 50 40 0 0 0 +40 B15 +IMID 0.375 + 25 55 0 0 0 +55 B15 + IMID 0.187 + 12.5 15 0 0 0 +15 B15 +IMID  1.5 + 200 80 30 0 30 +50 B15 + IMID  0.75 + 100 25 0 0 0 +25 B15 +IMID  1.5 + 400 85 30 0 30 +55 B15 + IMID  0.75 + 200 45 0 0 0 +45

In the above tables column 2 shows the application rates used, where thefirst rate given corresponds to the compound in column 4 and the secondrate given corresponds to the compound in column 5. Columns 4 and 5 showthe control observed from the compounds alone. Column 3 shows thecontrol observed from the combined application of both compounds. Datais not shown for experiments where there was no insect mortality whenthe compounds were applied alone and in combination, or where onecompound alone and the combination both resulted in complete mortality.When a compound applied alone gave no control at a particular rate, itis assumed that lower rates of that compound alone also give no control.DMET=deltamethrin, SPAT=spirotetramat, IMID=imidacloprid, B15=compound15 in Table B.

1. A pesticidal mixture comprising a component A and a component B,wherein component A is a compound of formula I

—B¹—B²—B³— is —C═N—O—, —C═N—CH₂— or —N—CH₂—CH₂—; Y¹ is C—R⁶, CH ornitrogen; Y² and Y³ are independently CH or nitrogen; wherein no morethan two of Y¹, Y² and Y³ are nitrogen and wherein Y² and Y³ are notboth nitrogen; R⁵ is hydrogen, halogen, cyano, nitro, NH₂, C₁-C₂alkyl,C₁-C₂haloalkyl, C₃-C₅cycloalkyl, C₃-C₅halocycloalkyl, C₁-C₂alkoxy,C₁-C₂haloalkoxy; R⁶ when present together with R⁵ forms a —CH═CH—CH═CH—bridge; R⁷ is hydrogen or methyl; R⁸ is C₁-C₄alkyl, C₁-C₄haloalkyl,C₁-C₄alkyl-O—CH₂—, C₁-C₄haloalkyl-O—CH₂—, C₃-C₆cycloalkyl,C₃-C₆cycloalkyl-CH₂—, C₁-C₄alkyl-S—CH₂—, C₁-C₄alkyl-S(O)—CH₂—,C₁-C₄alkyl-S(O₂)—CH₂—; X² is C—X⁶ or nitrogen; X¹, X³ and X⁶ areindependently hydrogen, halogen or trihalomethyl, wherein at least twoof X¹, X³ and X⁶ are not hydrogen; X⁴ is trifluoromethyl, difluoromethylor chlorodifluoromethyl; and component B is a compound selected from a)a pyrethroid including those selected from the group consisting ofpermethrin, cypermethrin, fenvalerate, esfenvalerate, deltamethrin,cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin, bifenthrin,fenpropathrin, cyfluthrin (including beta cyfluthrin), tefluthrin,ethofenprox, natural pyrethrin, tetramethrin, S-bioallethrin,fenfluthrin, prallethrin and5-benzyl-3-furylmethyl-(E)-(1R,3S)-2,2-dimethyl-3-(2-oxothiolan-3-ylidenemethyl)cyclopropanecarboxylate; b) an organophosphate including those selected from thegroup consisting of sulprofos, acephate, methyl parathion,azinphos-methyl, demeton-s-methyl, heptenophos, thiometon, fenamiphos,monocrotophos, profenofos, triazophos, methamidophos, dimethoate,phosphamidon, malathion, chlorpyrifos, phosalone, terbufos,fensulfothion, fonofos, phorate, phoxim, pirimiphos-methyl,pirimiphos-ethyl, fenitrothion, fosthiazate and diazinon; c) a carbamateincluding those selected from the group consisting of pirimicarb,triazamate, chloethocarb, carbofuran, furathiocarb, ethiofencarb,aldicarb, thiofurox, carbosulfan, bendiocarb, fenobucarb, propoxur,methomyl, thiodicarb and oxamyl; d) a benzoyl urea including thoseselected from the group consisting of diflubenzuron, triflumuron,hexaflumuron, flufenoxuron, lufenuron and chlorfluazuron; e) an organictin compound selected from the group consisting of cyhexatin, fenbutatinoxide and azocyclotin; f) a pyrazole including those selected from thegroup consisting of tebufenpyrad and fenpyroximate; g) a macrolideincluding those selected from the group consisting of abamectin,emamectin (e.g. emamectin benzoate), ivermectin, milbemycin, spinosad,azadirachtin and spinetoram; h) an organochlorine compound includingthose selected from the group consisting of endosulfan (in particularalpha-endosulfan), benzene hexachloride, DDT, chlordane and dieldrin; i)an amidine including those selected from the group consisting ofchlordimeform and amitraz; j) a fumigant agent including those selectedfrom the group consisting of chloropicrin, dichloropropane, methylbromide and metam; k) a neonicotinoid compound including those selectedfrom the group consisting of imidacloprid, thiacloprid, acetamiprid,nitenpyram, dinotefuran, thiamethoxam, clothianidin, nithiazine andflonicamid; l) a diacylhydrazine including those selected from the groupconsisting of tebufenozide, chromafenozide and methoxyfenozide; m) adiphenyl ether including those selected from the group consisting ofdiofenolan and pyriproxyfen; n) indoxacarb; o) chlorfenapyr; p)pymetrozine; q) a tetramic acid compound including those selected fromthe group consisting of spirotetramat and spirodiclofen, or a tetronicacid compound including spiromesifen; r) a diamide including thoseselected from the group consisting of flubendiamide, chlorantraniliprole(Rynaxypyr®) and cyantraniliprole; s) sulfoxaflor; t) metaflumizone; u)fipronil and ethiprole; v) pyrifluqinazon; w) buprofezin; x)diafenthiuron; y)4-[(6-Chloro-pyridin-3-ylmethyl)-(2,2-difluoro-ethyl)-amino]-5H-furan-2-one;z) flupyradifurone.
 2. A pesticidal mixture according to claim 1 whereinthe mixture is enriched for the compound of formula I**

relative to the compound of formula I*

wherein B¹, B², B³, X¹, X², X³, X⁴, Y¹, Y², Y³, R⁵, R⁷ and R⁸ are asdefined in claim
 1. 3. A pesticidal mixture according to claim 1,wherein —B¹—B²—B³— is —N—CH₂—CH₂—.
 4. A pesticidal mixture according toclaim 1, wherein R⁵ is hydrogen, chloro, bromo, fluoro, methyl, ortrifluoromethyl.
 5. A pesticidal mixture according to claim 1, whereinR⁸ is methyl, ethyl, CH₃—O—CH₂—, cyclopropyl or cyclopropyl-CH₂—,CF₃CH₂, CH₃S—CH₂, CH₃S(O₂)—CH₂.
 6. A pesticidal mixture according toclaim 1, wherein R⁸ is methyl, ethyl, CH₃—O—CH₂—, cyclopropyl orcyclopropyl-CH₂—.
 7. A pesticidal mixture according to claim 1, whereinY¹ is CH, Y² is CH, and Y³ is CH.
 8. A pesticidal mixture according toclaim 1, wherein X¹ is chloro, X² is CH, X³ is chloro or X¹ istrifluoromethyl, X² is CH, X³ is trifluoromethyl or X¹ is chloro, X² isC—Cl, X³ is chloro or X¹ is chloro, X² is CH, X³ is trifluoromethyl orX¹ is chloro, X² is C—F, X³ is chloro.
 9. A pesticidal mixture accordingto claim 1, wherein —B¹—B²—B³— is —N—CH₂—CH₂—, X² is C—X⁶, Y¹, Y², andY³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ is C₁-C₂alkyl,C₁-C₂alkyl-O—CH₂—, C₃-C₄cycloalkyl, or C₃-C₄cycloalkyl-CH₂—.
 10. Apesticidal mixture according to claim 1, wherein —B¹—B²—B³— is—N—CH₂—CH₂—, X² is C—X⁶, Y¹, Y², and Y³ are C—H, R⁵ is hydrogen, R⁸ ismethyl, ethyl, CH₃—O—CH₂—, cyclopropyl or cyclopropyl-CH₂—.
 11. Apesticidal mixture according to claim 1, wherein —B¹—B²—B³— is—N—CH₂—CH₂—, X² is C—X⁶, Y¹, Y², and Y³ are C—H, R⁵ is hydrogen, R⁷ ismethyl, R⁸ is cyclopropyl.
 12. A pesticidal mixture according to claim1, wherein —B¹—B²—B³— is —N—CH₂—CH₂—, Y¹, Y², and Y³ are C—H, R⁵ ishydrogen, R⁷ is methyl, R⁸ is cyclopropyl, X¹ is chloro, X² is CH, X³ ischloro or X¹ is trifluoromethyl, X² is CH, X³ is trifluoromethyl or X¹is chloro, X² is C—Cl, X³ is chloro or X¹ is chloro, X² is CH, X³ istrifluoromethyl or X¹ is chloro, X² is C—F, X³ is chloro.
 13. Apesticidal mixture according to claim 1, wherein —B¹—B²—B³— is—N—CH₂—CH₂—, Y¹, Y², and Y³ are C—H, R⁵ is hydrogen, R⁷ is methyl, R⁸ iscyclopropyl, X¹ is trifluoromethyl, X² is CH, X³ is trifluoromethyl, X⁴is trifluoromethyl.
 14. A pesticidal mixture according to claim 1wherein component B is a pyrethroid selected from the group consistingof permethrin, cypermethrin, fenvalerate, esfenvalerate, deltamethrin,cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin, bifenthrin,fenpropathrin, cyfluthrin (including beta cyfluthrin), tefluthrin,ethofenprox, natural pyrethrin, tetramethrin, S-bioallethrin,fenfluthrin, prallethrin and5-benzyl-3-furylmethyl-(E)-(1R,3S)-2,2-dimethyl-3-(2-oxothiolan-3-ylidenemethyl)cyclopropanecarboxylate; a neonicotinoid compound selected from the group consistingof imidacloprid, thiacloprid, acetamiprid, nitenpyram, dinotefuran,thiamethoxam, clothianidin, nithiazine and flonicamid; a tetramic acidor tetronic acid selected from the group consisting of spirotetramat,spirodiclofen and spiromesifen.
 15. A pesticidal mixture according toclaim 1, wherein component B is deltamethrin, spirotetramat orimidacloprid.
 16. A pesticidal mixture according to claim 9, whereincomponent B is spirotetramat.
 17. A pesticidal mixture according toclaim 9, wherein component B is imidacloprid.
 18. A pesticidal mixtureaccording to claim 9, wherein component B is deltamethrin.
 19. Apesticidal mixture according to claim 13, wherein component B isspirotetramat.
 20. A pesticidal mixture according to claim 13, whereincomponent B is deltamethrin.
 21. A pesticidal mixture according to claim13, wherein component B is imidacloprid.
 22. A pesticidal mixtureaccording to claim 1, wherein the weight ratio of A to B is 1000:1 to1:1000.
 23. A pesticidal mixture according to claim 1, wherein theweight ratio of A to B is 100:1 to 1:100.
 24. A method of controllinginsects, acarines, nematodes or molluscs which comprises applying to apest, to a locus of a pest, or to a plant susceptible to attack by apest a combination of components A and B, wherein components A and B areas defined in claim 1.